tetano
Editor, Senior Moderator
Front Mol Biosci
. 2022 Jan 14;8:796229.
doi: 10.3389/fmolb.2021.796229. eCollection 2021.
From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
Elnaz Aledavood[SUP] 1 2 [/SUP], Beatrice Selmi[SUP] 2 [/SUP], Carolina Estarellas[SUP] 1 [/SUP], Matteo Masetti[SUP] 2 [/SUP], F Javier Luque[SUP] 1 [/SUP]
Affiliations
Abstract
With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the M2 proton channel and neuraminidase. This review highlights the efforts spent in targeting the M2 proton channel, which mediates the proton transport toward the interior of the viral particle as a preliminary step leading to the release of the fusion peptide in hemagglutinin and the fusion of the viral and endosomal membranes. Besides the structural and mechanistic aspects of the M2 proton channel, attention is paid to the challenges posed by the development of efficient small molecule inhibitors and the evolution toward novel ligands and scaffolds motivated by the emergence of resistant strains.
Keywords: M2 proton channel; drug design; influenza A virus; inhibition; molecular mechanism; proton transport.
. 2022 Jan 14;8:796229.
doi: 10.3389/fmolb.2021.796229. eCollection 2021.
From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus
Elnaz Aledavood[SUP] 1 2 [/SUP], Beatrice Selmi[SUP] 2 [/SUP], Carolina Estarellas[SUP] 1 [/SUP], Matteo Masetti[SUP] 2 [/SUP], F Javier Luque[SUP] 1 [/SUP]
Affiliations
- PMID: 35096969
- PMCID: PMC8795881
- DOI: 10.3389/fmolb.2021.796229
Abstract
With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the M2 proton channel and neuraminidase. This review highlights the efforts spent in targeting the M2 proton channel, which mediates the proton transport toward the interior of the viral particle as a preliminary step leading to the release of the fusion peptide in hemagglutinin and the fusion of the viral and endosomal membranes. Besides the structural and mechanistic aspects of the M2 proton channel, attention is paid to the challenges posed by the development of efficient small molecule inhibitors and the evolution toward novel ligands and scaffolds motivated by the emergence of resistant strains.
Keywords: M2 proton channel; drug design; influenza A virus; inhibition; molecular mechanism; proton transport.