tetano
Editor, Senior Moderator
Front Immunol
. 2021 Sep 15;12:743022.
doi: 10.3389/fimmu.2021.743022. eCollection 2021.
The Effects of COVID-19 on the Placenta During Pregnancy
Habib Sadeghi Rad[SUP] 1 [/SUP], Joan Röhl[SUP] 1 [/SUP], Nataly Stylianou[SUP] 1 [/SUP], Mark C Allenby[SUP] 2 3 [/SUP], Sajad Razavi Bazaz[SUP] 4 [/SUP], Majid E Warkiani[SUP] 4 [/SUP], Fernando S F Guimaraes[SUP] 5 [/SUP], Vicki L Clifton[SUP] 6 [/SUP], Arutha Kulasinghe[SUP] 1 5 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregnancy-related complications in SARS-CoV-2 positive mothers, such as miscarriage, restricted fetal growth, or still-birth. In this review, we discuss the pathobiology of COVID-19 maternal infection and the potential adverse effects associated with viral infection, and the possibility of transplacental transmission.
Keywords: COVID-19; SARS-CoV-2; placenta; pregnancy; transplacental infection.
. 2021 Sep 15;12:743022.
doi: 10.3389/fimmu.2021.743022. eCollection 2021.
The Effects of COVID-19 on the Placenta During Pregnancy
Habib Sadeghi Rad[SUP] 1 [/SUP], Joan Röhl[SUP] 1 [/SUP], Nataly Stylianou[SUP] 1 [/SUP], Mark C Allenby[SUP] 2 3 [/SUP], Sajad Razavi Bazaz[SUP] 4 [/SUP], Majid E Warkiani[SUP] 4 [/SUP], Fernando S F Guimaraes[SUP] 5 [/SUP], Vicki L Clifton[SUP] 6 [/SUP], Arutha Kulasinghe[SUP] 1 5 [/SUP]
Affiliations
- PMID: 34603330
- PMCID: PMC8479199
- DOI: 10.3389/fimmu.2021.743022
Abstract
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregnancy-related complications in SARS-CoV-2 positive mothers, such as miscarriage, restricted fetal growth, or still-birth. In this review, we discuss the pathobiology of COVID-19 maternal infection and the potential adverse effects associated with viral infection, and the possibility of transplacental transmission.
Keywords: COVID-19; SARS-CoV-2; placenta; pregnancy; transplacental infection.