tetano
Editor, Senior Moderator
Front Immunol
. 2024 Jan 17:14:1235210.
doi: 10.3389/fimmu.2023.1235210. eCollection 2023. People who use drugs show no increase in pre-existing T-cell cross-reactivity toward SARS-CoV-2 but develop a normal polyfunctional T-cell response after standard mRNA vaccination
Murat Gainullin[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Lorenzo Federico[SUP] #[/SUP][SUP] 1 3 [/SUP], Julie Røkke Osen[SUP] 1 3 [/SUP], Viktoriia Chaban[SUP] 1 3 [/SUP], Hassen Kared[SUP] 1 3 [/SUP], Amin Alirezaylavasani[SUP] 1 3 [/SUP], Fridtjof Lund-Johansen[SUP] 3 4 5 [/SUP], Gull Wildendahl[SUP] 6 [/SUP], Jon-Aksel Jacobsen[SUP] 6 [/SUP], Hina Sarwar Anjum[SUP] 6 [/SUP], Richard Stratford[SUP] 2 [/SUP], Simen Tennøe[SUP] 2 [/SUP], Brandon Malone[SUP] 2 [/SUP], Trevor Clancy[SUP] 2 [/SUP], John T Vaage[SUP] 3 5 [/SUP], Kathleen Henriksen[SUP] 6 7 [/SUP], Linda Wüsthoff[SUP] #[/SUP][SUP] 8 9 [/SUP], Ludvig A Munthe[SUP] #[/SUP][SUP] 1 3 [/SUP]
Affiliations
People who use drugs (PWUD) are at a high risk of contracting and developing severe coronavirus disease 2019 (COVID-19) and other infectious diseases due to their lifestyle, comorbidities, and the detrimental effects of opioids on cellular immunity. However, there is limited research on vaccine responses in PWUD, particularly regarding the role that T cells play in the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we show that before vaccination, PWUD did not exhibit an increased frequency of preexisting cross-reactive T cells to SARS-CoV-2 and that, despite the inhibitory effects that opioids have on T-cell immunity, standard vaccination can elicit robust polyfunctional CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T-cell responses that were similar to those found in controls. Our findings indicate that vaccination stimulates an effective immune response in PWUD and highlight targeted vaccination as an essential public health instrument for the control of COVID-19 and other infectious diseases in this group of high-risk patients.
Keywords: SARS-CoV-2 vaccination; T cell functionality; T cell responses; T cell subsets; antiviral immunity; opioids and immune responses; people who use drugs.
. 2024 Jan 17:14:1235210.
doi: 10.3389/fimmu.2023.1235210. eCollection 2023. People who use drugs show no increase in pre-existing T-cell cross-reactivity toward SARS-CoV-2 but develop a normal polyfunctional T-cell response after standard mRNA vaccination
Murat Gainullin[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Lorenzo Federico[SUP] #[/SUP][SUP] 1 3 [/SUP], Julie Røkke Osen[SUP] 1 3 [/SUP], Viktoriia Chaban[SUP] 1 3 [/SUP], Hassen Kared[SUP] 1 3 [/SUP], Amin Alirezaylavasani[SUP] 1 3 [/SUP], Fridtjof Lund-Johansen[SUP] 3 4 5 [/SUP], Gull Wildendahl[SUP] 6 [/SUP], Jon-Aksel Jacobsen[SUP] 6 [/SUP], Hina Sarwar Anjum[SUP] 6 [/SUP], Richard Stratford[SUP] 2 [/SUP], Simen Tennøe[SUP] 2 [/SUP], Brandon Malone[SUP] 2 [/SUP], Trevor Clancy[SUP] 2 [/SUP], John T Vaage[SUP] 3 5 [/SUP], Kathleen Henriksen[SUP] 6 7 [/SUP], Linda Wüsthoff[SUP] #[/SUP][SUP] 8 9 [/SUP], Ludvig A Munthe[SUP] #[/SUP][SUP] 1 3 [/SUP]
Affiliations
- PMID: 38299149
- PMCID: PMC10827924
- DOI: 10.3389/fimmu.2023.1235210
People who use drugs (PWUD) are at a high risk of contracting and developing severe coronavirus disease 2019 (COVID-19) and other infectious diseases due to their lifestyle, comorbidities, and the detrimental effects of opioids on cellular immunity. However, there is limited research on vaccine responses in PWUD, particularly regarding the role that T cells play in the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we show that before vaccination, PWUD did not exhibit an increased frequency of preexisting cross-reactive T cells to SARS-CoV-2 and that, despite the inhibitory effects that opioids have on T-cell immunity, standard vaccination can elicit robust polyfunctional CD4[SUP]+[/SUP] and CD8[SUP]+[/SUP] T-cell responses that were similar to those found in controls. Our findings indicate that vaccination stimulates an effective immune response in PWUD and highlight targeted vaccination as an essential public health instrument for the control of COVID-19 and other infectious diseases in this group of high-risk patients.
Keywords: SARS-CoV-2 vaccination; T cell functionality; T cell responses; T cell subsets; antiviral immunity; opioids and immune responses; people who use drugs.