tetano
Editor, Senior Moderator
Front Immunol
. 2022 Nov 22;13:1053437.
doi: 10.3389/fimmu.2022.1053437. eCollection 2022.
Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives
Qiugang Zhu[SUP] 1 [/SUP], Yan Xu[SUP] 2 [/SUP], Ting Wang[SUP] 3 [/SUP], Feiting Xie[SUP] 4 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) has been a global pandemic, caused by a novel coronavirus strain with strong infectivity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the in-depth research, the close relationship between COVID-19 and immune system has been dug out. During the infection, macrophages, dendritic cells, natural killer cells, CD8[SUP]+[/SUP] T cells, Th1, Th17, Tfh cells and effector B cells are all involved in the anti-SARS-CoV-2 responses, however, the dysfunctional immune responses will ultimately lead to the excessive inflammation, acute lung injury, even other organ failure. Thus, a detailed understanding of pertinent immune response during COVID-19 will provide insights in predicting disease outcomes and developing appropriate therapeutic approaches. In this review, we mainly clarify the role of immune cells in COVID-19 and the target-vaccine development and treatment.
Keywords: COVID-19; SARS-CoV-2; immune responses; treatment; vaccination.
. 2022 Nov 22;13:1053437.
doi: 10.3389/fimmu.2022.1053437. eCollection 2022.
Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives
Qiugang Zhu[SUP] 1 [/SUP], Yan Xu[SUP] 2 [/SUP], Ting Wang[SUP] 3 [/SUP], Feiting Xie[SUP] 4 [/SUP]
Affiliations
- PMID: 36505489
- PMCID: PMC9727711
- DOI: 10.3389/fimmu.2022.1053437
Abstract
Coronavirus disease 2019 (COVID-19) has been a global pandemic, caused by a novel coronavirus strain with strong infectivity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the in-depth research, the close relationship between COVID-19 and immune system has been dug out. During the infection, macrophages, dendritic cells, natural killer cells, CD8[SUP]+[/SUP] T cells, Th1, Th17, Tfh cells and effector B cells are all involved in the anti-SARS-CoV-2 responses, however, the dysfunctional immune responses will ultimately lead to the excessive inflammation, acute lung injury, even other organ failure. Thus, a detailed understanding of pertinent immune response during COVID-19 will provide insights in predicting disease outcomes and developing appropriate therapeutic approaches. In this review, we mainly clarify the role of immune cells in COVID-19 and the target-vaccine development and treatment.
Keywords: COVID-19; SARS-CoV-2; immune responses; treatment; vaccination.