tetano
Editor, Senior Moderator
Front Immunol
. 2023 Dec 11:14:1242302.
doi: 10.3389/fimmu.2023.1242302. eCollection 2023. Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2
Muneto Izuhara[SUP] 1 2 [/SUP], Kentaro Matsui[SUP] 1 2 [/SUP], Takuya Yoshiike[SUP] 1 [/SUP], Aoi Kawamura[SUP] 1 [/SUP], Tomohiro Utsumi[SUP] 1 3 [/SUP], Kentaro Nagao[SUP] 1 4 [/SUP], Ayumi Tsuru[SUP] 1 2 [/SUP], Rei Otsuki[SUP] 5 [/SUP], Shingo Kitamura[SUP] 1 [/SUP], Kenichi Kuriyama[SUP] 1 [/SUP]
Affiliations
Introduction: Sleep enhances the antibody response to vaccination, but the relationship between sleep and mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully understood.
Methods: In this prospective observational study, we investigated the influence of sleep habits on immune acquisition induced by mRNA vaccines against SARS-CoV-2 in 48 healthy adults (BNT-162b2, n=34; mRNA-1273, n=14; female, n=30, 62.5%; male, n=18, 37.5%; median age, 39.5 years; interquartile range, 33.0-44.0 years) from June 2021 to January 2022. The study measured sleep duration using actigraphy and sleep diaries, which covered the periods of the initial and booster vaccinations.
Results: Multivariable linear regression analysis showed that actigraphy-measured objective sleep duration 3 and 7 days after the booster vaccination was independently and significantly correlated with higher antibody titers (B=0.003; 95% confidence interval, 0.000-0.005; Beta=0.337; p=0.02), even after controlling for covariates, including age, sex, the type of vaccine, and reactogenicity to the vaccination. Associations between acquired antibody titer and average objective sleep duration before vaccination, and any period of subjective sleep duration measured by sleep diary were negligible.
Discussion: Longer objective, but not subjective, sleep duration after booster vaccination enhances antibody response. Hence, encouraging citizens to sleep longer after mRNA vaccination, especially after a booster dose, may increase protection against SARS-CoV-2.
Study registration: This study is registered at the University Hospital Medical Information Network Center (UMIN: https://www.umin.ac.jp) on July 30, 2021, #UMIN000045009.
Keywords: BNT-162b2; antibody titer; longer objective sleep duration; mRNA SARS-CoV-2 vaccine; mRNA-1273; sleep and immunity.
. 2023 Dec 11:14:1242302.
doi: 10.3389/fimmu.2023.1242302. eCollection 2023. Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2
Muneto Izuhara[SUP] 1 2 [/SUP], Kentaro Matsui[SUP] 1 2 [/SUP], Takuya Yoshiike[SUP] 1 [/SUP], Aoi Kawamura[SUP] 1 [/SUP], Tomohiro Utsumi[SUP] 1 3 [/SUP], Kentaro Nagao[SUP] 1 4 [/SUP], Ayumi Tsuru[SUP] 1 2 [/SUP], Rei Otsuki[SUP] 5 [/SUP], Shingo Kitamura[SUP] 1 [/SUP], Kenichi Kuriyama[SUP] 1 [/SUP]
Affiliations
- PMID: 38149250
- PMCID: PMC10750410
- DOI: 10.3389/fimmu.2023.1242302
Introduction: Sleep enhances the antibody response to vaccination, but the relationship between sleep and mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully understood.
Methods: In this prospective observational study, we investigated the influence of sleep habits on immune acquisition induced by mRNA vaccines against SARS-CoV-2 in 48 healthy adults (BNT-162b2, n=34; mRNA-1273, n=14; female, n=30, 62.5%; male, n=18, 37.5%; median age, 39.5 years; interquartile range, 33.0-44.0 years) from June 2021 to January 2022. The study measured sleep duration using actigraphy and sleep diaries, which covered the periods of the initial and booster vaccinations.
Results: Multivariable linear regression analysis showed that actigraphy-measured objective sleep duration 3 and 7 days after the booster vaccination was independently and significantly correlated with higher antibody titers (B=0.003; 95% confidence interval, 0.000-0.005; Beta=0.337; p=0.02), even after controlling for covariates, including age, sex, the type of vaccine, and reactogenicity to the vaccination. Associations between acquired antibody titer and average objective sleep duration before vaccination, and any period of subjective sleep duration measured by sleep diary were negligible.
Discussion: Longer objective, but not subjective, sleep duration after booster vaccination enhances antibody response. Hence, encouraging citizens to sleep longer after mRNA vaccination, especially after a booster dose, may increase protection against SARS-CoV-2.
Study registration: This study is registered at the University Hospital Medical Information Network Center (UMIN: https://www.umin.ac.jp) on July 30, 2021, #UMIN000045009.
Keywords: BNT-162b2; antibody titer; longer objective sleep duration; mRNA SARS-CoV-2 vaccine; mRNA-1273; sleep and immunity.