tetano
Editor, Senior Moderator
Front Genet
. 2020 Sep 25;11:564741.
doi: 10.3389/fgene.2020.564741. eCollection 2020.
Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India
Anshika Srivastava[SUP] 1 [/SUP], Audditiya Bandopadhyay[SUP] 1 [/SUP], Debashurti Das[SUP] 1 [/SUP], Rudra Kumar Pandey[SUP] 1 [/SUP], Vanya Singh[SUP] 1 [/SUP], Nargis Khanam[SUP] 1 [/SUP], Nikhil Srivastava[SUP] 1 [/SUP], Prajjval Pratap Singh[SUP] 1 [/SUP], Pavan Kumar Dubey[SUP] 2 [/SUP], Abhishek Pathak[SUP] 3 [/SUP], Pranav Gupta[SUP] 4 [/SUP], Niraj Rai[SUP] 5 [/SUP], Gazi Nurun Nahar Sultana[SUP] 6 [/SUP], Gyaneshwer Chaubey[SUP] 1 [/SUP]
Affiliations
Abstract
Studies on host-pathogen interaction have identified human ACE2 as a host cell receptor responsible for mediating infection by coronavirus (COVID-19). Subsequent studies have shown striking difference of allele frequency among Europeans and Asians for a polymorphism rs2285666, present in ACE2. It has been revealed that the alternate allele (TT-plus strand or AA-minus strand) of rs2285666 elevate the expression level of this gene upto 50%, hence may play a significant role in SARS-CoV-2 susceptibility. Therefore, we have first looked the phylogenetic structure of rs2285666 derived haplotypes in worldwide populations and compared the spatial frequency of this particular allele with respect to the COVID-19 infection as well as case-fatality rate in India. For the first time, we ascertained a significant positive correlation for alternate allele (T or A) of rs2285666, with the lower infection as well as case-fatality rate among Indian populations. We trust that this information will be useful to understand the role of ACE2 in COVID-19 susceptibility.
Keywords: ACE2; COVID-19; India; SARS-CoV-2; coronavirus; rs2285666.
. 2020 Sep 25;11:564741.
doi: 10.3389/fgene.2020.564741. eCollection 2020.
Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India
Anshika Srivastava[SUP] 1 [/SUP], Audditiya Bandopadhyay[SUP] 1 [/SUP], Debashurti Das[SUP] 1 [/SUP], Rudra Kumar Pandey[SUP] 1 [/SUP], Vanya Singh[SUP] 1 [/SUP], Nargis Khanam[SUP] 1 [/SUP], Nikhil Srivastava[SUP] 1 [/SUP], Prajjval Pratap Singh[SUP] 1 [/SUP], Pavan Kumar Dubey[SUP] 2 [/SUP], Abhishek Pathak[SUP] 3 [/SUP], Pranav Gupta[SUP] 4 [/SUP], Niraj Rai[SUP] 5 [/SUP], Gazi Nurun Nahar Sultana[SUP] 6 [/SUP], Gyaneshwer Chaubey[SUP] 1 [/SUP]
Affiliations
- PMID: 33101387
- PMCID: PMC7545580
- DOI: 10.3389/fgene.2020.564741
Abstract
Studies on host-pathogen interaction have identified human ACE2 as a host cell receptor responsible for mediating infection by coronavirus (COVID-19). Subsequent studies have shown striking difference of allele frequency among Europeans and Asians for a polymorphism rs2285666, present in ACE2. It has been revealed that the alternate allele (TT-plus strand or AA-minus strand) of rs2285666 elevate the expression level of this gene upto 50%, hence may play a significant role in SARS-CoV-2 susceptibility. Therefore, we have first looked the phylogenetic structure of rs2285666 derived haplotypes in worldwide populations and compared the spatial frequency of this particular allele with respect to the COVID-19 infection as well as case-fatality rate in India. For the first time, we ascertained a significant positive correlation for alternate allele (T or A) of rs2285666, with the lower infection as well as case-fatality rate among Indian populations. We trust that this information will be useful to understand the role of ACE2 in COVID-19 susceptibility.
Keywords: ACE2; COVID-19; India; SARS-CoV-2; coronavirus; rs2285666.