tetano
Editor, Senior Moderator
Front Cell Infect Microbiol
. 2021 Jun 7;11:688007.
doi: 10.3389/fcimb.2021.688007. eCollection 2021.
Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
Cheng Zhang[SUP] 1 2 [/SUP], Kangkang Guo[SUP] 1 2 [/SUP], Huan Cui[SUP] 2 3 [/SUP], Ligong Chen[SUP] 1 [/SUP], Chunmao Zhang[SUP] 2 [/SUP], Xuejing Wang[SUP] 1 [/SUP], Jiaming Li[SUP] 4 [/SUP], Yingying Fu[SUP] 4 [/SUP], Zhongyi Wang[SUP] 4 [/SUP], Zhendong Guo[SUP] 2 [/SUP], Juxiang Liu[SUP] 1 [/SUP], Shishan Dong[SUP] 1 [/SUP]
Affiliations
Abstract
Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China. We found that this isolate could be transmitted by direct contact and aerosol in mammals. More importantly, after 5 passages in mice, the virus acquired two adaptive mutations, PB1-H115Q and B2-E627K, exhibiting increased virulence and aerosol transmissibility. These results suggest that this H7N9 virus might potentially be transmitted between humans through environmental or airborne routes.
Keywords: H7N9 virus; environmental and airborne transmissibility; human exposure risk; mammalian adaption; pathogenicity.
. 2021 Jun 7;11:688007.
doi: 10.3389/fcimb.2021.688007. eCollection 2021.
Risk of Environmental Exposure to H7N9 Influenza Virus via Airborne and Surface Routes in a Live Poultry Market in Hebei, China
Cheng Zhang[SUP] 1 2 [/SUP], Kangkang Guo[SUP] 1 2 [/SUP], Huan Cui[SUP] 2 3 [/SUP], Ligong Chen[SUP] 1 [/SUP], Chunmao Zhang[SUP] 2 [/SUP], Xuejing Wang[SUP] 1 [/SUP], Jiaming Li[SUP] 4 [/SUP], Yingying Fu[SUP] 4 [/SUP], Zhongyi Wang[SUP] 4 [/SUP], Zhendong Guo[SUP] 2 [/SUP], Juxiang Liu[SUP] 1 [/SUP], Shishan Dong[SUP] 1 [/SUP]
Affiliations
- PMID: 34164347
- PMCID: PMC8216215
- DOI: 10.3389/fcimb.2021.688007
Abstract
Environmental transmission of viruses to humans has become an early warning for potential epidemic outbreaks, such as SARS-CoV-2 and influenza virus outbreaks. Recently, an H7N9 virus, A/environment/Hebei/621/2019 (H7N9), was isolated by environmental swabs from a live poultry market in Hebei, China. We found that this isolate could be transmitted by direct contact and aerosol in mammals. More importantly, after 5 passages in mice, the virus acquired two adaptive mutations, PB1-H115Q and B2-E627K, exhibiting increased virulence and aerosol transmissibility. These results suggest that this H7N9 virus might potentially be transmitted between humans through environmental or airborne routes.
Keywords: H7N9 virus; environmental and airborne transmissibility; human exposure risk; mammalian adaption; pathogenicity.