tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2013 Jul 9;9(11). [Epub ahead of print]
Formulation and immunological evaluation of a trivalent vaccine comprising emulsified submicron particles and inactivated virions of H5N1/EV71/JEV.
Lin CW, Chang CY, Chen WL, Lin SC, Liao CC, Chang JY, Liu CC, Yung-Chi Hu A, Lu TC, Chou AH, Wu SC, Chong P, Huang MH.
Source
National Institute of Infectious Diseases and Vaccinology; National Health Research Institutes; Zhunan, Taiwan.
Abstract
Combination vaccines can reduce the number of injections and simplify the immunization schedule required to prevent different diseases. Here we assessed the immunogenicity in a mouse model of a vaccine composition comprising inactivated influenza viruses (H5N1/H1N1), enterovirus 71 (EV71), and/or Japanese encephalitis virus (JEV) and investigated whether the vaccine formulations can overcome the immunologic interference between the individual vaccine components. We demonstrated that the antigenic competition happens between H5N1/H1N1 or H5N1/EV71 inactivated virions when the vaccine combinations either formulated with Alum suspensions or without adjuvant. In the presence of PELC emulsified particles, EV71-specific immune responses before and after incorporating H5N1 virus into EV71 vaccine was detected of no significant difference; in addition, H5N1- and EV71-specific immune responses were found at the same level when H5N1/EV71/JEV consolidating into combination vaccine. Emulsified vaccine formulation was represented as a potential tool that is found to reduce the number of injections required to prevent multiple infectious strains causing the same disease (H5N1/H1N1) and/or that protect against different diseases (H5N1/EV71). Combination vaccines can also include a third component to protect against H5N1/EV71/JEV at the same time.
KEYWORDS:
Japanese encephalitis, adjuvant, combination vaccine, enterovirus 71, influenza
PMID:
23838466
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23838466
Formulation and immunological evaluation of a trivalent vaccine comprising emulsified submicron particles and inactivated virions of H5N1/EV71/JEV.
Lin CW, Chang CY, Chen WL, Lin SC, Liao CC, Chang JY, Liu CC, Yung-Chi Hu A, Lu TC, Chou AH, Wu SC, Chong P, Huang MH.
Source
National Institute of Infectious Diseases and Vaccinology; National Health Research Institutes; Zhunan, Taiwan.
Abstract
Combination vaccines can reduce the number of injections and simplify the immunization schedule required to prevent different diseases. Here we assessed the immunogenicity in a mouse model of a vaccine composition comprising inactivated influenza viruses (H5N1/H1N1), enterovirus 71 (EV71), and/or Japanese encephalitis virus (JEV) and investigated whether the vaccine formulations can overcome the immunologic interference between the individual vaccine components. We demonstrated that the antigenic competition happens between H5N1/H1N1 or H5N1/EV71 inactivated virions when the vaccine combinations either formulated with Alum suspensions or without adjuvant. In the presence of PELC emulsified particles, EV71-specific immune responses before and after incorporating H5N1 virus into EV71 vaccine was detected of no significant difference; in addition, H5N1- and EV71-specific immune responses were found at the same level when H5N1/EV71/JEV consolidating into combination vaccine. Emulsified vaccine formulation was represented as a potential tool that is found to reduce the number of injections required to prevent multiple infectious strains causing the same disease (H5N1/H1N1) and/or that protect against different diseases (H5N1/EV71). Combination vaccines can also include a third component to protect against H5N1/EV71/JEV at the same time.
KEYWORDS:
Japanese encephalitis, adjuvant, combination vaccine, enterovirus 71, influenza
PMID:
23838466
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23838466