tetano
Editor, Senior Moderator
Cold Spring Harb Perspect Med. 2019 Dec 23. pii: a038323. doi: 10.1101/cshperspect.a038323. [Epub ahead of print] [h=1]Ferreting Out Influenza Virus Pathogenicity and Transmissibility: Past and Future Risk Assessments in the Ferret Model.[/h]
Belser JA[SUP]1[/SUP], Pulit-Penaloza JA[SUP]1[/SUP], Maines TR[SUP]1[/SUP].
[h=3]Author information[/h] 1 Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA.
[h=3]Abstract[/h] As influenza A viruses continue to jump species barriers, data generated in the ferret model to assess influenza virus pathogenicity, transmissibility, and tropism of these novel strains continues to inform an increasing scope of public health-based applications. This review presents the suitability of ferrets as a small mammalian model for influenza viruses and describes the breadth of pathogenicity and transmissibility profiles possible in this species following inoculation with a diverse range of viruses. Adaptation of aerobiology-based techniques and analyses have furthered our understanding of data obtained from this model and provide insight into the capacity of novel and emerging influenza viruses to cause human infection and disease.
Copyright ? 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PMID: 31871233 DOI: 10.1101/cshperspect.a038323
Belser JA[SUP]1[/SUP], Pulit-Penaloza JA[SUP]1[/SUP], Maines TR[SUP]1[/SUP].
[h=3]Author information[/h] 1 Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA.
[h=3]Abstract[/h] As influenza A viruses continue to jump species barriers, data generated in the ferret model to assess influenza virus pathogenicity, transmissibility, and tropism of these novel strains continues to inform an increasing scope of public health-based applications. This review presents the suitability of ferrets as a small mammalian model for influenza viruses and describes the breadth of pathogenicity and transmissibility profiles possible in this species following inoculation with a diverse range of viruses. Adaptation of aerobiology-based techniques and analyses have furthered our understanding of data obtained from this model and provide insight into the capacity of novel and emerging influenza viruses to cause human infection and disease.
Copyright ? 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
PMID: 31871233 DOI: 10.1101/cshperspect.a038323