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Factors associated with real time RT-PCR cycle threshold values among medically attended influenza episodes

tetano

Editor, Senior Moderator
J Med Virol. 2015 Sep 3. doi: 10.1002/jmv.24373. [Epub ahead of print]
[h=1]Factors associated with real time RT-PCR cycle threshold values among medically attended influenza episodes.[/h] Spencer S[SUP]1,[/SUP][SUP]2[/SUP], Clippard J[SUP]1,[/SUP][SUP]2[/SUP], Thompson M[SUP]1[/SUP], Piedra PA[SUP]3,[/SUP][SUP]4[/SUP], Jewell A[SUP]3[/SUP], Avadhanula V[SUP]3[/SUP], Mei M[SUP]3[/SUP], Jackson ML[SUP]5[/SUP], Meece J[SUP]6[/SUP], Sundaram M[SUP]6[/SUP], Belongia EA[SUP]6[/SUP], Cross R[SUP]7[/SUP], Johnson E[SUP]7[/SUP], Bullotta A[SUP]8[/SUP], Rinaldo C[SUP]8[/SUP], Gaglani M[SUP]9[/SUP], Murthy K[SUP]9[/SUP], Clipper L[SUP]9[/SUP], Berman L[SUP]1[/SUP], Flannery B[SUP]1[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] We evaluated the cycle threshold (CT) values of 1160 influenza A positive and 806 influenza B positive specimens from two seasons of the US Flu VE Network to identify factors associated with CT values. Low CT values (high genomic load) were associated with shorter intervals between illness onset and specimen collection, young age (ages 3-8 years old), and self-rated illness severity for both influenza A and B. Low CT values were also associated with reported fever/feverishness and age ≥65 years for influenza A. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.


[h=4]KEYWORDS:[/h] Influenza; RT-PCR; cycle threshold value

PMID: 26334765 [PubMed - as supplied by publisher]
 
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