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Expression of Profi brotic Growth Factors and Their Receptors by Mouse Lung Macrophages and Fibroblasts under Conditions of Acute Viral Infl ammation

tetano

Editor, Senior Moderator
Bull Exp Biol Med. 2014 Apr;156(6):833-7. doi: 10.1007/s10517-014-2463-7. Epub 2014 May 3.
Expression of Profi brotic Growth Factors and Their Receptors by Mouse Lung Macrophages and Fibroblasts under Conditions of Acute Viral Infl ammation in Infl uenza A/H5N1 Virus.
Anikina AG1, Shkurupii VA, Potapova OV, Kovner AV, Shestopalov AM.
Author information
Abstract

Morphological signs of early interstitial fi brosis, developing under conditions of acute viral inflammation (postinfection days 1-14), were observed in C57Bl/6 mice infected with influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus. The development of fi brosis was confirmed by an increase in the number of lung cells expressing TNF-α. These changes were recorded in the presence of a many-fold increase in the counts of macrophages and fi broblasts expressing FGF, EGF, and their receptors.

PMID:
24824710
[PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/24824710
 
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