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[h=1]Evidence for Transmission of Zika Virus by Platelet Transfusion[/h] August 17, 2016DOI: 10.1056/NEJMc1607262
Article Metrics [h=3]To the Editor:[/h] Zika virus (ZIKV) is a mosquito-borne virus that has important secondary means of transmission that include perinatal and sexual modes.1-3 The potential for transmission in transfused donated blood components has been a concern owing to the detection of ZIKV viremia in healthy blood donors.4
This report from Brazil describes two cases of likely ZIKV transmission by blood transfusion from one presymptomatic infected person who donated platelets by apheresis on January 16, 2016. The two leukodepleted platelet units were irradiated with 25 Gy delivered by an IBL-437C gamma irradiator (Cis Bio International) and were transfused in different patients on January 19 (day 0). On January 21, the donor called the blood bank to report a cutaneous rash, retro-orbital pain, and pain in both knees that had begun on January 18. An investigation was initiated under the hospital?s clinical protocol for transfusion-associated adverse events, with the donor and both patients providing written informed consent.
...
The first recipient (Patient 1) was a 54-year-old woman with the primary myelofibrosis syndrome. The second recipient (Patient 2) was a 14-year-old girl with acute myeloid leukemia who had undergone haploidentical bone marrow transplantation on January 6, after which she had been receiving continuous immunosuppressive therapy. Routine pretransfusion samples obtained from the two patients were negative on PCR assay for CHIKV, DENV, and ZIKV, but samples collected 6 days after platelet transfusion in Patient 1 and 23 to 51 days after platelet transfusion in Patient 2 were positive for ZIKV on PCR assay.
...
http://www.nejm.org/doi/full/10.1056/NEJMc1607262?query=featured_home&#t=article
[h=1]Evidence for Transmission of Zika Virus by Platelet Transfusion[/h] August 17, 2016DOI: 10.1056/NEJMc1607262
Article Metrics [h=3]To the Editor:[/h] Zika virus (ZIKV) is a mosquito-borne virus that has important secondary means of transmission that include perinatal and sexual modes.1-3 The potential for transmission in transfused donated blood components has been a concern owing to the detection of ZIKV viremia in healthy blood donors.4
This report from Brazil describes two cases of likely ZIKV transmission by blood transfusion from one presymptomatic infected person who donated platelets by apheresis on January 16, 2016. The two leukodepleted platelet units were irradiated with 25 Gy delivered by an IBL-437C gamma irradiator (Cis Bio International) and were transfused in different patients on January 19 (day 0). On January 21, the donor called the blood bank to report a cutaneous rash, retro-orbital pain, and pain in both knees that had begun on January 18. An investigation was initiated under the hospital?s clinical protocol for transfusion-associated adverse events, with the donor and both patients providing written informed consent.
...
The first recipient (Patient 1) was a 54-year-old woman with the primary myelofibrosis syndrome. The second recipient (Patient 2) was a 14-year-old girl with acute myeloid leukemia who had undergone haploidentical bone marrow transplantation on January 6, after which she had been receiving continuous immunosuppressive therapy. Routine pretransfusion samples obtained from the two patients were negative on PCR assay for CHIKV, DENV, and ZIKV, but samples collected 6 days after platelet transfusion in Patient 1 and 23 to 51 days after platelet transfusion in Patient 2 were positive for ZIKV on PCR assay.
...
http://www.nejm.org/doi/full/10.1056/NEJMc1607262?query=featured_home&#t=article