tetano
Editor, Senior Moderator
J Hosp Infect. 2014 Feb 27. pii: S0195-6701(14)00059-0. doi: 10.1016/j.jhin.2014.02.003. [Epub ahead of print]
Evaluating the virucidal efficacy of hydrogen peroxide vapour.
Goyal SM1, Chander Y2, Yezli S3, Otter JA4.
Author information
Abstract
BACKGROUND:
Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents.
AIM:
To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, for the inactivation of a number of structurally distinct viruses of importance in the healthcare, veterinary and public sectors. The viruses studied were: feline calicivirus (FCV, a norovirus surrogate); human adenovirus type 1; transmissible gastroenteritis coronavirus of pigs (TGEV, a severe acute respiratory syndrome coronavirus [SARS-CoV] surrogate); avian influenza virus (AIV); and swine influenza virus (SwIV).
METHODS:
The viruses were dried on stainless steel discs in 20- or 40-μL aliquots and exposed to HPV produced by a Clarus L generator (Bioquell, Horsham, PA, USA) in a 0.2-m3 environmental chamber. Three vaporized volumes of hydrogen peroxide were tested in triplicate for each virus: 25, 27 and 33mL.
FINDINGS:
No viable viruses were identified after HPV exposure at any of the vaporized volumes tested. HPV was virucidal (>4-log reduction) against FCV, adenovirus, TGEV and AIV at the lowest vaporized volume tested (25mL). For SwIV, due to low virus titre on the control discs, >3.8-log reduction was shown for the 25-mL vaporized volume and >4-log reduction was shown for the 27-mL and 33-mL vaporized volumes.
CONCLUSION:
HPV was virucidal for structurally distinct viruses dried on surfaces, suggesting that HPV can be considered for the disinfection of virus-contaminated surfaces.
Copyright ? 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Adenovirus, Decontamination, Disinfection, Feline calicivirus, HPV, Hydrogen peroxide vapour, Influenza virus, Norovirus, SARS, Transmissible gastroenteritis virus
PMID:
24656442
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24656442
Evaluating the virucidal efficacy of hydrogen peroxide vapour.
Goyal SM1, Chander Y2, Yezli S3, Otter JA4.
Author information
Abstract
BACKGROUND:
Surface contamination has been implicated in the transmission of certain viruses, and surface disinfection can be an effective measure to interrupt the spread of these agents.
AIM:
To evaluate the in-vitro efficacy of hydrogen peroxide vapour (HPV), a vapour-phase disinfection method, for the inactivation of a number of structurally distinct viruses of importance in the healthcare, veterinary and public sectors. The viruses studied were: feline calicivirus (FCV, a norovirus surrogate); human adenovirus type 1; transmissible gastroenteritis coronavirus of pigs (TGEV, a severe acute respiratory syndrome coronavirus [SARS-CoV] surrogate); avian influenza virus (AIV); and swine influenza virus (SwIV).
METHODS:
The viruses were dried on stainless steel discs in 20- or 40-μL aliquots and exposed to HPV produced by a Clarus L generator (Bioquell, Horsham, PA, USA) in a 0.2-m3 environmental chamber. Three vaporized volumes of hydrogen peroxide were tested in triplicate for each virus: 25, 27 and 33mL.
FINDINGS:
No viable viruses were identified after HPV exposure at any of the vaporized volumes tested. HPV was virucidal (>4-log reduction) against FCV, adenovirus, TGEV and AIV at the lowest vaporized volume tested (25mL). For SwIV, due to low virus titre on the control discs, >3.8-log reduction was shown for the 25-mL vaporized volume and >4-log reduction was shown for the 27-mL and 33-mL vaporized volumes.
CONCLUSION:
HPV was virucidal for structurally distinct viruses dried on surfaces, suggesting that HPV can be considered for the disinfection of virus-contaminated surfaces.
Copyright ? 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Adenovirus, Decontamination, Disinfection, Feline calicivirus, HPV, Hydrogen peroxide vapour, Influenza virus, Norovirus, SARS, Transmissible gastroenteritis virus
PMID:
24656442
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24656442