Giuseppe
Emeritus
Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009?2011 (Euro Surveill., abstract, edited)
[Source: Eurosurveillance, full text: <cite cite="http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19807">Eurosurveillance - View Article</cite>. Abstract, edited.]
Eurosurveillance, Volume 16, Issue 9, 03 March 2011
Rapid communications
Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009?2011
G C Mak 1, C K Leung 1, K C Cheng 1, K Y Wong 1, W Lim 1
1. Virology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Kowloon, Hong Kong
Citation style for this article: Mak GC, Leung CK, Cheng KC, Wong KY, Lim W. Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009?2011. Euro Surveill. 2011;16(9)
ii=19807. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19807
Date of submission: 24 February 2011
Phylogenetic analysis of the haemagglutinin (HA) gene shows that the influenza A(H1N1)2009 viruses collected in Hong Kong clustered in two main branches characterised by the E391E and E391K amino acids. The main branch E391K evolved in two sub-branches with N142D and S202T mutations that first appeared in March and July 2010, respectively, with the latter becoming the predominant strain. These genetic variants that emerged display similar antigenic characteristics. Concurrent with genetic surveillance, laboratories should continue monitoring the circulating viruses antigenically.
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Eurosurveillance, Volume 16, Issue 9, 03 March 2011
Rapid communications
Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009?2011
G C Mak 1, C K Leung 1, K C Cheng 1, K Y Wong 1, W Lim 1
1. Virology Division, Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Kowloon, Hong Kong
Citation style for this article: Mak GC, Leung CK, Cheng KC, Wong KY, Lim W. Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009?2011. Euro Surveill. 2011;16(9)
ii=19807. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19807Date of submission: 24 February 2011
Phylogenetic analysis of the haemagglutinin (HA) gene shows that the influenza A(H1N1)2009 viruses collected in Hong Kong clustered in two main branches characterised by the E391E and E391K amino acids. The main branch E391K evolved in two sub-branches with N142D and S202T mutations that first appeared in March and July 2010, respectively, with the latter becoming the predominant strain. These genetic variants that emerged display similar antigenic characteristics. Concurrent with genetic surveillance, laboratories should continue monitoring the circulating viruses antigenically.
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