tetano
Editor, Senior Moderator
Eur Respir J
. 2021 Jul 1;2101341.
doi: 10.1183/13993003.01341-2021. Online ahead of print.
Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study
Ismail M Osmanov[SUP] 1 2 3 [/SUP], Ekaterina Spiridonova[SUP] 4 3 [/SUP], Polina Bobkova[SUP] 4 3 [/SUP], Aysylu Gamirova[SUP] 4 3 [/SUP], Anastasia Shikhaleva[SUP] 4 3 [/SUP], Margarita Andreeva[SUP] 4 3 [/SUP], Oleg Blyuss[SUP] 4 5 3 [/SUP], Yasmin El-Taravi[SUP] 4 [/SUP], Audrey DunnGalvin[SUP] 4 6 [/SUP], Pasquale Comberiati[SUP] 7 [/SUP], Diego G Peroni[SUP] 7 [/SUP], Christian Apfelbacher[SUP] 8 [/SUP], Jon Genuneit[SUP] 9 [/SUP], Lyudmila Mazankova[SUP] 10 [/SUP], Alexandra Miroshina[SUP] 1 [/SUP], Evgeniya Chistyakova[SUP] 11 [/SUP], Elmira Samitova[SUP] 1 10 [/SUP], Svetlana Borzakova[SUP] 2 12 [/SUP], Elena Bondarenko[SUP] 4 [/SUP], Anatoliy A Korsunskiy[SUP] 4 [/SUP], Irina Konova[SUP] 1 [/SUP], Sarah Wulf Hanson[SUP] 13 [/SUP], Gail Carson[SUP] 14 [/SUP], Louise Sigfrid[SUP] 14 [/SUP], Janet T Scott[SUP] 15 [/SUP], Matthew Greenhawt[SUP] 16 [/SUP], Elizabeth A Whittaker[SUP] 17 [/SUP], Elena Garralda[SUP] 18 [/SUP], Olivia Swann[SUP] 19 20 [/SUP], Danilo Buonsenso[SUP] 21 22 23 [/SUP], Dasha E Nicholls[SUP] 18 [/SUP], Frances Simpson[SUP] 24 [/SUP], Christina Jones[SUP] 25 [/SUP], Malcolm G Semple[SUP] 26 27 [/SUP], John O Warner[SUP] 28 [/SUP], Theo Vos[SUP] 13 [/SUP], Piero Olliaro[SUP] 14 [/SUP], Daniel Munblit[SUP] 29 28 30 3 [/SUP], Sechenov StopCOVID Research Team
Affiliations
Abstract
Background: The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.
Methods: This is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.
Findings: 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3-15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age "6-11 years" (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and "12-18 years" (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).
Interpretation: A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.
. 2021 Jul 1;2101341.
doi: 10.1183/13993003.01341-2021. Online ahead of print.
Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study
Ismail M Osmanov[SUP] 1 2 3 [/SUP], Ekaterina Spiridonova[SUP] 4 3 [/SUP], Polina Bobkova[SUP] 4 3 [/SUP], Aysylu Gamirova[SUP] 4 3 [/SUP], Anastasia Shikhaleva[SUP] 4 3 [/SUP], Margarita Andreeva[SUP] 4 3 [/SUP], Oleg Blyuss[SUP] 4 5 3 [/SUP], Yasmin El-Taravi[SUP] 4 [/SUP], Audrey DunnGalvin[SUP] 4 6 [/SUP], Pasquale Comberiati[SUP] 7 [/SUP], Diego G Peroni[SUP] 7 [/SUP], Christian Apfelbacher[SUP] 8 [/SUP], Jon Genuneit[SUP] 9 [/SUP], Lyudmila Mazankova[SUP] 10 [/SUP], Alexandra Miroshina[SUP] 1 [/SUP], Evgeniya Chistyakova[SUP] 11 [/SUP], Elmira Samitova[SUP] 1 10 [/SUP], Svetlana Borzakova[SUP] 2 12 [/SUP], Elena Bondarenko[SUP] 4 [/SUP], Anatoliy A Korsunskiy[SUP] 4 [/SUP], Irina Konova[SUP] 1 [/SUP], Sarah Wulf Hanson[SUP] 13 [/SUP], Gail Carson[SUP] 14 [/SUP], Louise Sigfrid[SUP] 14 [/SUP], Janet T Scott[SUP] 15 [/SUP], Matthew Greenhawt[SUP] 16 [/SUP], Elizabeth A Whittaker[SUP] 17 [/SUP], Elena Garralda[SUP] 18 [/SUP], Olivia Swann[SUP] 19 20 [/SUP], Danilo Buonsenso[SUP] 21 22 23 [/SUP], Dasha E Nicholls[SUP] 18 [/SUP], Frances Simpson[SUP] 24 [/SUP], Christina Jones[SUP] 25 [/SUP], Malcolm G Semple[SUP] 26 27 [/SUP], John O Warner[SUP] 28 [/SUP], Theo Vos[SUP] 13 [/SUP], Piero Olliaro[SUP] 14 [/SUP], Daniel Munblit[SUP] 29 28 30 3 [/SUP], Sechenov StopCOVID Research Team
Affiliations
- PMID: 34210789
- DOI: 10.1183/13993003.01341-2021
Abstract
Background: The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.
Methods: This is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.
Findings: 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3-15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age "6-11 years" (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and "12-18 years" (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).
Interpretation: A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.