tetano
Editor, Senior Moderator
Eur J Nutr
. 2023 Dec 19.
doi: 10.1007/s00394-023-03298-3. Online ahead of print. Association between vitamin D deficiency and post-acute outcomes of SARS-CoV-2 infection
Jheng-Yan Wu[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Mei-Yuan Liu[SUP] #[/SUP][SUP] 1 4 5 6 [/SUP], Wan-Hsuan Hsu[SUP] 7 [/SUP], Ya-Wen Tsai[SUP] 8 [/SUP], Ting-Hui Liu[SUP] 9 [/SUP], Po-Yu Huang[SUP] 10 [/SUP], Min-Hsiang Chuang[SUP] 10 [/SUP], Szu-En Chin[SUP] 11 [/SUP], Chih-Cheng Lai[SUP] 12 13 [/SUP]
Affiliations
Objectives: This study aimed to investigate the association between vitamin D deficiency (VDD) and post-acute outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: This retrospective study used the TriNetX research network to identify COVID-19 patients between January 1 and November 30, 2022. Patients were matched using propensity score matching (PSM) and divided into VDD (< 20 ng/mL) and control (≥ 20 ng/mL) groups. The primary outcome was a composite of post-COVID-19 condition (identified by ICD-10 code), all-cause emergency department (ED) visits, hospitalization, and death during the follow-up period (90-180 days) after the diagnosis of COVID-19.
Results: From an initial recruitment of 42,674 non-hospitalized patients with COVID-19 and known 25(OH)D status, a VDD group of 8300 was identified and propensity matched with 8300 controls. During the follow-up period, the VDD group had a higher risk of the primary outcome than did the control group [hazard ratio (HR) = 1.122; 95% confidence interval (CI) = 1.041-1.210]. The VDD group also had a higher risk of all-cause ED visits (HR = 1.114; 95% CI = 1.012-1.226), all-cause hospitalization (HR = 1.230; 95% CI = 1.105-1.369), and all-cause death (HR = 1.748; 95% CI = 1.047-2.290) but not post-COVID-19 condition (HR = 0.980; 95% CI = 0.630-1.523), individually.
Conclusion: Among the COVID-19 patients, VDD might be associated with a higher risk of all-cause ED visits, hospitalization, and death during the post-acute phase.
Keywords: Hospitalization; Long COVID; Mortality; Post-COVID-19 condition; SARS-CoV-2; Vitamin D.
. 2023 Dec 19.
doi: 10.1007/s00394-023-03298-3. Online ahead of print. Association between vitamin D deficiency and post-acute outcomes of SARS-CoV-2 infection
Jheng-Yan Wu[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Mei-Yuan Liu[SUP] #[/SUP][SUP] 1 4 5 6 [/SUP], Wan-Hsuan Hsu[SUP] 7 [/SUP], Ya-Wen Tsai[SUP] 8 [/SUP], Ting-Hui Liu[SUP] 9 [/SUP], Po-Yu Huang[SUP] 10 [/SUP], Min-Hsiang Chuang[SUP] 10 [/SUP], Szu-En Chin[SUP] 11 [/SUP], Chih-Cheng Lai[SUP] 12 13 [/SUP]
Affiliations
- PMID: 38112761
- DOI: 10.1007/s00394-023-03298-3
Objectives: This study aimed to investigate the association between vitamin D deficiency (VDD) and post-acute outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: This retrospective study used the TriNetX research network to identify COVID-19 patients between January 1 and November 30, 2022. Patients were matched using propensity score matching (PSM) and divided into VDD (< 20 ng/mL) and control (≥ 20 ng/mL) groups. The primary outcome was a composite of post-COVID-19 condition (identified by ICD-10 code), all-cause emergency department (ED) visits, hospitalization, and death during the follow-up period (90-180 days) after the diagnosis of COVID-19.
Results: From an initial recruitment of 42,674 non-hospitalized patients with COVID-19 and known 25(OH)D status, a VDD group of 8300 was identified and propensity matched with 8300 controls. During the follow-up period, the VDD group had a higher risk of the primary outcome than did the control group [hazard ratio (HR) = 1.122; 95% confidence interval (CI) = 1.041-1.210]. The VDD group also had a higher risk of all-cause ED visits (HR = 1.114; 95% CI = 1.012-1.226), all-cause hospitalization (HR = 1.230; 95% CI = 1.105-1.369), and all-cause death (HR = 1.748; 95% CI = 1.047-2.290) but not post-COVID-19 condition (HR = 0.980; 95% CI = 0.630-1.523), individually.
Conclusion: Among the COVID-19 patients, VDD might be associated with a higher risk of all-cause ED visits, hospitalization, and death during the post-acute phase.
Keywords: Hospitalization; Long COVID; Mortality; Post-COVID-19 condition; SARS-CoV-2; Vitamin D.