tetano
Editor, Senior Moderator
Eur J Med Res
. 2023 Mar 27;28(1):136.
doi: 10.1186/s40001-023-01086-7.
Retrospective study on the efficacy of monocyte distribution width (MDW) as a screening test for COVID-19
Kentaro Wakamatsu[SUP] 1 [/SUP], Zenzo Nagasawa[SUP] 2 [/SUP], Kouta Katsuki[SUP] 3 [/SUP], Hiroyuki Kumazoe[SUP] 4 [/SUP], Masayo Yasuda[SUP] 3 [/SUP], Sae Kawamoto[SUP] 3 [/SUP], Ayano Kawamura[SUP] 3 [/SUP], Tsuyoshi Ueno[SUP] 4 [/SUP], Ruriko Kiyotani[SUP] 4 [/SUP], Izumi Fukui[SUP] 4 [/SUP], Sanae Maki[SUP] 4 [/SUP], Nobuhiko Nagata[SUP] 5 [/SUP], Masayuki Kawasaki[SUP] 4 [/SUP], Hozumi Yamada[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Pathogenic genetic testing for coronavirus disease 2019 (COVID-19) can detect viruses with high sensitivity; however, there are several challenges. In the prevention, testing, and treatment of COVID-19, more effective, safer, and convenient methods are desired. We evaluated the possibility of monocyte distribution width (MDW) as an infection biomarker in COVID-19 testing.
Methods: The efficacy of MDW as a screening test for COVID-19 was retrospectively assessed in 80 patients in the COVID-19 group and 232 patients in the non-COVID-19 group (141 patients with acute respiratory infection, 19 patients with nonrespiratory infection, one patient with a viral infection, 11 patients who had received treatment for COVID-19, one patient in contact with COVID-19 patients, and 59 patients with noninfectious disease).
Results: The median MDW in 80 patients in the COVID-19 group was 23.3 (17.2-33.6), and the median MDW in 232 patients in the non-COVID-19 group was 19.0 (13.6-30.2) (P < 0.001). When the COVID-19 group was identified using the MDW cut-off value of 21.3 from the non-COVID-19 group, the area under the curve (AUC) was 0.844, and the sensitivity and specificity were 81.3% and 78.2%, respectively. Comparison of MDW by severity between the COVID-19 group and patients with acute respiratory infection in the non-COVID-19 group showed that MDW was significantly higher in the COVID-19 group for all mild, moderate I, and moderate II disease.
Conclusions: MDW (cut-off value: 21.3) may be used as a screening test for COVID-19 in fever outpatients. Trial registration This study was conducted after being approved by the ethics committee of National Hospital Organization Omuta National Hospital (Approval No. 3-19). This study can be accessed via https://omuta.hosp.go.jp/files/000179721.pdf .
Keywords: Coronavirus disease 2019 (COVID-19); DxH 900; Monocyte; Monocyte distribution width (MDW); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
. 2023 Mar 27;28(1):136.
doi: 10.1186/s40001-023-01086-7.
Retrospective study on the efficacy of monocyte distribution width (MDW) as a screening test for COVID-19
Kentaro Wakamatsu[SUP] 1 [/SUP], Zenzo Nagasawa[SUP] 2 [/SUP], Kouta Katsuki[SUP] 3 [/SUP], Hiroyuki Kumazoe[SUP] 4 [/SUP], Masayo Yasuda[SUP] 3 [/SUP], Sae Kawamoto[SUP] 3 [/SUP], Ayano Kawamura[SUP] 3 [/SUP], Tsuyoshi Ueno[SUP] 4 [/SUP], Ruriko Kiyotani[SUP] 4 [/SUP], Izumi Fukui[SUP] 4 [/SUP], Sanae Maki[SUP] 4 [/SUP], Nobuhiko Nagata[SUP] 5 [/SUP], Masayuki Kawasaki[SUP] 4 [/SUP], Hozumi Yamada[SUP] 6 [/SUP]
Affiliations
- PMID: 36973757
- DOI: 10.1186/s40001-023-01086-7
Abstract
Background: Pathogenic genetic testing for coronavirus disease 2019 (COVID-19) can detect viruses with high sensitivity; however, there are several challenges. In the prevention, testing, and treatment of COVID-19, more effective, safer, and convenient methods are desired. We evaluated the possibility of monocyte distribution width (MDW) as an infection biomarker in COVID-19 testing.
Methods: The efficacy of MDW as a screening test for COVID-19 was retrospectively assessed in 80 patients in the COVID-19 group and 232 patients in the non-COVID-19 group (141 patients with acute respiratory infection, 19 patients with nonrespiratory infection, one patient with a viral infection, 11 patients who had received treatment for COVID-19, one patient in contact with COVID-19 patients, and 59 patients with noninfectious disease).
Results: The median MDW in 80 patients in the COVID-19 group was 23.3 (17.2-33.6), and the median MDW in 232 patients in the non-COVID-19 group was 19.0 (13.6-30.2) (P < 0.001). When the COVID-19 group was identified using the MDW cut-off value of 21.3 from the non-COVID-19 group, the area under the curve (AUC) was 0.844, and the sensitivity and specificity were 81.3% and 78.2%, respectively. Comparison of MDW by severity between the COVID-19 group and patients with acute respiratory infection in the non-COVID-19 group showed that MDW was significantly higher in the COVID-19 group for all mild, moderate I, and moderate II disease.
Conclusions: MDW (cut-off value: 21.3) may be used as a screening test for COVID-19 in fever outpatients. Trial registration This study was conducted after being approved by the ethics committee of National Hospital Organization Omuta National Hospital (Approval No. 3-19). This study can be accessed via https://omuta.hosp.go.jp/files/000179721.pdf .
Keywords: Coronavirus disease 2019 (COVID-19); DxH 900; Monocyte; Monocyte distribution width (MDW); Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).