tetano
Editor, Senior Moderator
Eur J Med Res
. 2024 Oct 4;29(1):484.
doi: 10.1186/s40001-024-02062-5. Does early combination vs. Monotherapy improve clinical outcomes of clinically extremely vulnerable patients with COVID-19? Results from a retrospective propensity-weighted analysis
Mazzitelli Maria[SUP] #[/SUP][SUP] 1 [/SUP], Alberto Enrico Maraolo[SUP] #[/SUP][SUP] 2 [/SUP], Claudia Cozzolino[SUP] 3 [/SUP], Lolita Sasset[SUP] 4 [/SUP], Anna Ferrari[SUP] 4 [/SUP], Monica Basso[SUP] 4 [/SUP], Eleonora Vania[SUP] 4 [/SUP], Nicola Bonadiman[SUP] 4 [/SUP], Vincenzo Scaglione[SUP] 4 [/SUP], Anna Maria Cattelan[SUP] 4 [/SUP]
Affiliations
Background: The potential efficacy of early combination therapy, based on an antiviral plus a monoclonal antibody, for COVID-19 in severely immunocompromised patients is matter of debate.
Objectives: Our aim was to describe the impact on clinical outcomes of COVID-19 treatments in severely immunocompromised individuals, evaluating differences between a combination and a monotherapy.
Methods: We included severely immunocompromised outpatients with mild-to-moderate COVID-19 who received an early treatment (either monotherapy with nirmatrelvir/ritonavir or remdesivir or the combination of an antiviral plus sotrovimab). We then assessed differences between the two treatment strategies on three main outcomes (30-day mortality, access to emergency department, hospitalization), separately and as a composite by using a propensity score weighted (PSW) approach.
Results: Eighty one severely immunocompromised patients were included, 39 receiving early combination therapy and 42 receiving monotherapy. No significant difference was observed in the 30-day mortality rate and hospitalization rate between subjects in the two groups, while access to the emergency department following treatment administration was significantly higher in people who received a combination therapy. After applying the PSW, it was observed that combination therapy impacted favourably on the composite outcome, in a statistically significant fashion. In addition, PSW approach for mortality showed that age was the only significant factor influencing the death as stand-alone outcome.
Conclusions: Early combination therapy showed a favourable impact on a composite outcome (including mortality, hospitalizations and access to emergency department) in severely immunocompromised hosts who were all vaccinated. However, further studies are needed to support our results.
Keywords: Combined treatment; Early treatment; Monotherapy; SARS-CoV-2; Severe immunocompromised patients.
. 2024 Oct 4;29(1):484.
doi: 10.1186/s40001-024-02062-5. Does early combination vs. Monotherapy improve clinical outcomes of clinically extremely vulnerable patients with COVID-19? Results from a retrospective propensity-weighted analysis
Mazzitelli Maria[SUP] #[/SUP][SUP] 1 [/SUP], Alberto Enrico Maraolo[SUP] #[/SUP][SUP] 2 [/SUP], Claudia Cozzolino[SUP] 3 [/SUP], Lolita Sasset[SUP] 4 [/SUP], Anna Ferrari[SUP] 4 [/SUP], Monica Basso[SUP] 4 [/SUP], Eleonora Vania[SUP] 4 [/SUP], Nicola Bonadiman[SUP] 4 [/SUP], Vincenzo Scaglione[SUP] 4 [/SUP], Anna Maria Cattelan[SUP] 4 [/SUP]
Affiliations
- PMID: 39367485
- PMCID: PMC11451216
- DOI: 10.1186/s40001-024-02062-5
Background: The potential efficacy of early combination therapy, based on an antiviral plus a monoclonal antibody, for COVID-19 in severely immunocompromised patients is matter of debate.
Objectives: Our aim was to describe the impact on clinical outcomes of COVID-19 treatments in severely immunocompromised individuals, evaluating differences between a combination and a monotherapy.
Methods: We included severely immunocompromised outpatients with mild-to-moderate COVID-19 who received an early treatment (either monotherapy with nirmatrelvir/ritonavir or remdesivir or the combination of an antiviral plus sotrovimab). We then assessed differences between the two treatment strategies on three main outcomes (30-day mortality, access to emergency department, hospitalization), separately and as a composite by using a propensity score weighted (PSW) approach.
Results: Eighty one severely immunocompromised patients were included, 39 receiving early combination therapy and 42 receiving monotherapy. No significant difference was observed in the 30-day mortality rate and hospitalization rate between subjects in the two groups, while access to the emergency department following treatment administration was significantly higher in people who received a combination therapy. After applying the PSW, it was observed that combination therapy impacted favourably on the composite outcome, in a statistically significant fashion. In addition, PSW approach for mortality showed that age was the only significant factor influencing the death as stand-alone outcome.
Conclusions: Early combination therapy showed a favourable impact on a composite outcome (including mortality, hospitalizations and access to emergency department) in severely immunocompromised hosts who were all vaccinated. However, further studies are needed to support our results.
Keywords: Combined treatment; Early treatment; Monotherapy; SARS-CoV-2; Severe immunocompromised patients.