tetano
Editor, Senior Moderator
Eur Heart J Suppl
. 2023 Feb 14;25(Suppl A):A12-A16.
doi: 10.1093/eurheartjsupp/suac122. eCollection 2023 Feb.
Myocardial infarction and viral triggers: what do we know by now?
Daniel Caldeira[SUP] 1 2 3 4 [/SUP], Beatriz Nogueira-Garcia[SUP] 1 2 [/SUP]
Affiliations
Abstract
Myocardial infarction (MI) is an acute clinical manifestation ischaemic heart disease, which is the leading cause of death worldwide. Infections also have an important burden worldwide, with lower respiratory infections being the worldwide leading cause of death due to communicable diseases. The relationship of MI with viral respiratory infections (including influenza and SARS-CoV-2) as a trigger has been well documented with significant associations. These infections can lead to Type 1 MI, where inflammation and vascular dysfunction, as well as the increased prothrombotic environment lead to atherothrombosis. Type 2 MI may also occur due to an imbalance of oxygen/blood supply and myocardial demand (hypoxaemia, fever, and tachycardia). The data from randomized controlled trials showing a potential benefit of influenza vaccination in coronary artery disease patients should not be ignored. This can be considered a further argument for the association of viral infections (influenza in particular) and MI.
Keywords: Acute coronary syndrome; COVID-19; Influenza vaccine; Myocardial injury; Troponin.
. 2023 Feb 14;25(Suppl A):A12-A16.
doi: 10.1093/eurheartjsupp/suac122. eCollection 2023 Feb.
Myocardial infarction and viral triggers: what do we know by now?
Daniel Caldeira[SUP] 1 2 3 4 [/SUP], Beatriz Nogueira-Garcia[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36937373
- PMCID: PMC10021489
- DOI: 10.1093/eurheartjsupp/suac122
Abstract
Myocardial infarction (MI) is an acute clinical manifestation ischaemic heart disease, which is the leading cause of death worldwide. Infections also have an important burden worldwide, with lower respiratory infections being the worldwide leading cause of death due to communicable diseases. The relationship of MI with viral respiratory infections (including influenza and SARS-CoV-2) as a trigger has been well documented with significant associations. These infections can lead to Type 1 MI, where inflammation and vascular dysfunction, as well as the increased prothrombotic environment lead to atherothrombosis. Type 2 MI may also occur due to an imbalance of oxygen/blood supply and myocardial demand (hypoxaemia, fever, and tachycardia). The data from randomized controlled trials showing a potential benefit of influenza vaccination in coronary artery disease patients should not be ignored. This can be considered a further argument for the association of viral infections (influenza in particular) and MI.
Keywords: Acute coronary syndrome; COVID-19; Influenza vaccine; Myocardial injury; Troponin.