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Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN.
Influenza Other Respi Viruses. 2012 Feb 23;
Authors: Jules A, Grijalva CG, Zhu Y, Talbot KH, Williams JV, Dupont WD, Edwards KM, Schaffner W, Shay DK, Griffin MR
Abstract
Please cite this paper as: Jules et al. (2012) Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN. Influenza and Other Respiratory Viruses DOI:. 10.1111/j.1750-2659.2012.00343.x. Background In April 2009, a pandemic caused by a novel influenza strain, the A(H1N1)pdm09 virus, started. Few age-specific estimates of hospitalizations associated with the first year of circulation of the pandemic virus are available. Objectives To estimate age-specific hospitalization rates associated with laboratory-confirmed A(H1N1)pdm09 virus in Davidson County, TN, from May 2009 to March 2010. Patients/methods Two separate strategies were applied: capture-recapture and surveillance-sampling methods. For the capture-recapture estimates, we linked data collected via two independent prospective population-based surveillance systems: The Influenza Vaccine Effectiveness Network (Flu-VE) tested consenting county patients hospitalized with respiratory symptoms at selected hospitals using real-time reverse transcriptase polymerase chain reaction (rRT-PCR); the Emerging Infections Program identified county patients with positive influenza tests in all area hospitals. For the surveillance-sampling estimates, we applied the age-specific proportions of influenza-positive patients (from Flu-VE) to the number of acute respiratory illness hospitalizations obtained from the Tennessee Hospital Discharge Data system. Results With capture-recapture, we estimated 0?89 (95% CI, 0?72-1?49), 0?62 (0?42-1?11), 1?78 (0?99-3?63), and 0?76 (0?50-1?76) hospitalizations per 1000 residents aged <5, 5-17, 18-49, and ≥50 years, respectively. Surveillance-sampling estimated rates were 0?78 (0?46-1?22), 0?32 (0?14-0?69), 0?99 (0?64-1?52), and 1?43 (0?80-2?48) hospitalizations per 1000 residents aged <5, 5-17, 18-49, and ≥50 years, respectively. In all age-groups combined, we estimated approximately 1 influenza-related hospitalization per 1000 residents. Conclusions Two independent methods provided consistent results on the burden of pandemic virus in Davidson County and suggested that the overall incidence of A(H1N1)pdm09-associated hospitalization was 1 per 1000 county residents.
PMID: 22360812 [PubMed - as supplied by publisher]
http://whatarethesymptomsof.info/20...ing-the-pandemic-h1n1-2009-in-davidson-co-tn/
Influenza Other Respi Viruses. 2012 Feb 23;
Authors: Jules A, Grijalva CG, Zhu Y, Talbot KH, Williams JV, Dupont WD, Edwards KM, Schaffner W, Shay DK, Griffin MR
Abstract
Please cite this paper as: Jules et al. (2012) Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN. Influenza and Other Respiratory Viruses DOI:. 10.1111/j.1750-2659.2012.00343.x. Background In April 2009, a pandemic caused by a novel influenza strain, the A(H1N1)pdm09 virus, started. Few age-specific estimates of hospitalizations associated with the first year of circulation of the pandemic virus are available. Objectives To estimate age-specific hospitalization rates associated with laboratory-confirmed A(H1N1)pdm09 virus in Davidson County, TN, from May 2009 to March 2010. Patients/methods Two separate strategies were applied: capture-recapture and surveillance-sampling methods. For the capture-recapture estimates, we linked data collected via two independent prospective population-based surveillance systems: The Influenza Vaccine Effectiveness Network (Flu-VE) tested consenting county patients hospitalized with respiratory symptoms at selected hospitals using real-time reverse transcriptase polymerase chain reaction (rRT-PCR); the Emerging Infections Program identified county patients with positive influenza tests in all area hospitals. For the surveillance-sampling estimates, we applied the age-specific proportions of influenza-positive patients (from Flu-VE) to the number of acute respiratory illness hospitalizations obtained from the Tennessee Hospital Discharge Data system. Results With capture-recapture, we estimated 0?89 (95% CI, 0?72-1?49), 0?62 (0?42-1?11), 1?78 (0?99-3?63), and 0?76 (0?50-1?76) hospitalizations per 1000 residents aged <5, 5-17, 18-49, and ≥50 years, respectively. Surveillance-sampling estimated rates were 0?78 (0?46-1?22), 0?32 (0?14-0?69), 0?99 (0?64-1?52), and 1?43 (0?80-2?48) hospitalizations per 1000 residents aged <5, 5-17, 18-49, and ≥50 years, respectively. In all age-groups combined, we estimated approximately 1 influenza-related hospitalization per 1000 residents. Conclusions Two independent methods provided consistent results on the burden of pandemic virus in Davidson County and suggested that the overall incidence of A(H1N1)pdm09-associated hospitalization was 1 per 1000 county residents.
PMID: 22360812 [PubMed - as supplied by publisher]
http://whatarethesymptomsof.info/20...ing-the-pandemic-h1n1-2009-in-davidson-co-tn/