tetano
Editor, Senior Moderator
Epilepsy Behav
. 2022 Jun 29;134:108822.
doi: 10.1016/j.yebeh.2022.108822. Online ahead of print.
Should patients with epilepsy be vaccinated against coronavirus disease 2019? A systematic review and meta-analysis
Kan Lin[SUP] 1 [/SUP], Huayao Huang[SUP] 2 [/SUP], Shuangfang Fang[SUP] 3 [/SUP], Guanyi Zheng[SUP] 1 [/SUP], Kailong Fu[SUP] 1 [/SUP], Nan Liu[SUP] 4 [/SUP], Houwei Du[SUP] 5 [/SUP]
Affiliations
Abstract
Objective: The coronavirus disease 2019 (COVID-19) vaccination coverage, willingness, and safety profiles in patients with epilepsy remain poorly understood. We aimed to summarize the available evidence of COVID-19 vaccination coverage, willingness, and safety profiles among patients with epilepsy.
Methods: We performed a literature search in the Pubmed, EMBASE, and Cochrane Central Register database between 1 January 2020 and 30 April 2022. We included eligible studies that provided information on the COVID-19 vaccination coverage, willingness, and safety profiles among patients with epilepsy. We investigated the association between baseline characteristics of patients with epilepsy and unvaccination status using a fixed-effect model. We calculated the pooled overall willingness to be vaccinated against COVID-19. We systematically reviewed the safety profiles after COVID-19 vaccination in patients with epilepsy.
Results: Ten eligible observational studies and two case reports yielded 2589 participants with epilepsy or their caregivers. Among 2145 participants that provided the information of vaccination status, 1508 (70.3%) patients with epilepsy were not administered COVID-19 vaccine, and 58% (95%CI 40-75%) of respondents were willing to be vaccinated against COVID-19. Seizure status (active versus inactive, OR 1.84 95%CI 1.41-2.39, I[SUP]2[/SUP] = 0%) rather than seizure type (focal versus non-focal, OR 1.22 95%CI 0.94-1.58, I[SUP]2[/SUP] = 0%) was associated with COVID-19 unvaccination status. Vaccines were well-tolerated; epilepsy-related problems such as increase in seizure frequency and status epilepticus after COVID-19 vaccination were uncommon.
Conclusions: Our findings suggest a low COVID-19 vaccination coverage and willingness in patients with epilepsy. Vaccination against COVID-19 appears to be well-tolerated and safe in patients with epilepsy, supporting a positive outlook toward vaccination in this population.
Keywords: Adverse effect; COVID-19; Epilepsy; Seizure; Vaccines.
. 2022 Jun 29;134:108822.
doi: 10.1016/j.yebeh.2022.108822. Online ahead of print.
Should patients with epilepsy be vaccinated against coronavirus disease 2019? A systematic review and meta-analysis
Kan Lin[SUP] 1 [/SUP], Huayao Huang[SUP] 2 [/SUP], Shuangfang Fang[SUP] 3 [/SUP], Guanyi Zheng[SUP] 1 [/SUP], Kailong Fu[SUP] 1 [/SUP], Nan Liu[SUP] 4 [/SUP], Houwei Du[SUP] 5 [/SUP]
Affiliations
- PMID: 35853315
- DOI: 10.1016/j.yebeh.2022.108822
Abstract
Objective: The coronavirus disease 2019 (COVID-19) vaccination coverage, willingness, and safety profiles in patients with epilepsy remain poorly understood. We aimed to summarize the available evidence of COVID-19 vaccination coverage, willingness, and safety profiles among patients with epilepsy.
Methods: We performed a literature search in the Pubmed, EMBASE, and Cochrane Central Register database between 1 January 2020 and 30 April 2022. We included eligible studies that provided information on the COVID-19 vaccination coverage, willingness, and safety profiles among patients with epilepsy. We investigated the association between baseline characteristics of patients with epilepsy and unvaccination status using a fixed-effect model. We calculated the pooled overall willingness to be vaccinated against COVID-19. We systematically reviewed the safety profiles after COVID-19 vaccination in patients with epilepsy.
Results: Ten eligible observational studies and two case reports yielded 2589 participants with epilepsy or their caregivers. Among 2145 participants that provided the information of vaccination status, 1508 (70.3%) patients with epilepsy were not administered COVID-19 vaccine, and 58% (95%CI 40-75%) of respondents were willing to be vaccinated against COVID-19. Seizure status (active versus inactive, OR 1.84 95%CI 1.41-2.39, I[SUP]2[/SUP] = 0%) rather than seizure type (focal versus non-focal, OR 1.22 95%CI 0.94-1.58, I[SUP]2[/SUP] = 0%) was associated with COVID-19 unvaccination status. Vaccines were well-tolerated; epilepsy-related problems such as increase in seizure frequency and status epilepticus after COVID-19 vaccination were uncommon.
Conclusions: Our findings suggest a low COVID-19 vaccination coverage and willingness in patients with epilepsy. Vaccination against COVID-19 appears to be well-tolerated and safe in patients with epilepsy, supporting a positive outlook toward vaccination in this population.
Keywords: Adverse effect; COVID-19; Epilepsy; Seizure; Vaccines.