tetano
Editor, Senior Moderator
Int J Infect Dis. 2017 Nov 8. pii: S1201-9712(17)30200-X. doi: 10.1016/j.ijid.2017.07.021. [Epub ahead of print]
[h=1]Epidemiological and clinical characteristics of humans with avian influenza A (H7N9) infection in Guangdong, China, 2013-2017.[/h] Yang Y[SUP]1[/SUP], Zhong H[SUP]1[/SUP], Song T[SUP]1[/SUP], He J[SUP]1[/SUP], Guo L[SUP]2[/SUP], Tan X[SUP]1[/SUP], Huang G[SUP]1[/SUP], Kang M[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To describe the demographics and clinical characteristics of patients with A (H7N9) infection, to test the differences in the distribution of demographics and clinical characteristics by clinical severity, and to explore potential factors associated with clinical severity.
[h=4]METHODS:[/h] This retrospective study was conducted to collect epidemiological and clinical information regarding the confirmed cases in Guangdong through field investigation and review of medical records.
[h=4]RESULTS:[/h] Of the 256 cases, 100 (39.0%) patients died, and 168 (65.6%) patients were admitted to ICUs. The male-to-female ratio was approximately 2.0:1, and the median age was 56 years (range, 1 to 88). Among the 215 patients accepting oseltamivir treatment, the median time from the onset of illness to oseltamivir treatment was 5days (range, 0 to 16); 35 patients received zanamivir treatment after a median of 8days (range, 0 to 23). The univariable logistic regression models demonstrated that time from the onset of illness to oseltamivir treatment (OR=1.10, 95% CI=1.01-1.10) and zanamivir treatment (OR=1.05, 95% CI=1.02-1.07) were associated with the death of patients.
[h=4]CONCLUSIONS:[/h] Preventive measures should focus on high-risk populations, such as the elderly and the groups with high frequency exposure to live poultry. Earlier oseltamivir and zanamivir treatment were recommended.
Copyright ? 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Avian influenza; Clinical characteristics; Epidemiological characteristics; H7N9 subtype
PMID: 29128273 DOI: 10.1016/j.ijid.2017.07.021
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[h=1]Epidemiological and clinical characteristics of humans with avian influenza A (H7N9) infection in Guangdong, China, 2013-2017.[/h] Yang Y[SUP]1[/SUP], Zhong H[SUP]1[/SUP], Song T[SUP]1[/SUP], He J[SUP]1[/SUP], Guo L[SUP]2[/SUP], Tan X[SUP]1[/SUP], Huang G[SUP]1[/SUP], Kang M[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] To describe the demographics and clinical characteristics of patients with A (H7N9) infection, to test the differences in the distribution of demographics and clinical characteristics by clinical severity, and to explore potential factors associated with clinical severity.
[h=4]METHODS:[/h] This retrospective study was conducted to collect epidemiological and clinical information regarding the confirmed cases in Guangdong through field investigation and review of medical records.
[h=4]RESULTS:[/h] Of the 256 cases, 100 (39.0%) patients died, and 168 (65.6%) patients were admitted to ICUs. The male-to-female ratio was approximately 2.0:1, and the median age was 56 years (range, 1 to 88). Among the 215 patients accepting oseltamivir treatment, the median time from the onset of illness to oseltamivir treatment was 5days (range, 0 to 16); 35 patients received zanamivir treatment after a median of 8days (range, 0 to 23). The univariable logistic regression models demonstrated that time from the onset of illness to oseltamivir treatment (OR=1.10, 95% CI=1.01-1.10) and zanamivir treatment (OR=1.05, 95% CI=1.02-1.07) were associated with the death of patients.
[h=4]CONCLUSIONS:[/h] Preventive measures should focus on high-risk populations, such as the elderly and the groups with high frequency exposure to live poultry. Earlier oseltamivir and zanamivir treatment were recommended.
Copyright ? 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Avian influenza; Clinical characteristics; Epidemiological characteristics; H7N9 subtype
PMID: 29128273 DOI: 10.1016/j.ijid.2017.07.021
Free full text