tetano
Editor, Senior Moderator
J Dairy Sci. 2018 Oct 10. pii: S0022-0302(18)30962-7. doi: 10.3168/jds.2018-15137. [Epub ahead of print]
[h=1]Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice.[/h] Kim DH[SUP]1[/SUP], Chung WC[SUP]2[/SUP], Chun SH[SUP]1[/SUP], Han JH[SUP]2[/SUP], Song MJ[SUP]3[/SUP], Lee KW[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.
[h=4]KEYWORDS:[/h] anti-influenza; heat-treated Lactobacillus plantarum nF1; natural killer cell activity; yogurt
PMID: 30316596 DOI: 10.3168/jds.2018-15137
[h=1]Enhancing the natural killer cell activity and anti-influenza effect of heat-treated Lactobacillus plantarum nF1-fortified yogurt in mice.[/h] Kim DH[SUP]1[/SUP], Chung WC[SUP]2[/SUP], Chun SH[SUP]1[/SUP], Han JH[SUP]2[/SUP], Song MJ[SUP]3[/SUP], Lee KW[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A virus (IAV) infection is a global public health concern. It causes respiratory diseases ranging from mild illness to fatal disease. Natural killer (NK) cells are an innate immune component that kill infected cells and secrete cytokines to modulate the adaptive immune system; they constitute the first-line defense and play important roles in controlling IAV infection. This study evaluated the effect of daily administration of heat-treated Lactobacillus plantarum nF1-fortified yogurt on immunity and protection against IAV infection. Mice administered with heat-treated L. plantarum nF1-fortified yogurt showed elevated NK cell-related cytokine expression levels. Daily administration of the L. plantarum nF1-fortified yogurt before IAV infection also enhanced splenic NK activity, lung inflammatory cytokine responses, and survival rate. Thus, daily administration of nF1-fortified yogurt enhances host immunity and helps prevent IAV infection.
[h=4]KEYWORDS:[/h] anti-influenza; heat-treated Lactobacillus plantarum nF1; natural killer cell activity; yogurt
PMID: 30316596 DOI: 10.3168/jds.2018-15137