tetano
Editor, Senior Moderator
Emerg Infect Dis. 2018 Apr;24(4):746-750. doi: 10.3201/eid2404.171509.
[h=1]Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans.[/h] Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y.
[h=3]Abstract[/h] To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.
[h=4]KEYWORDS:[/h] H7N9; Highly pathogenic; PA; PB2; enhanced polymerase activity; influenza; respiratory infections; viruses
PMID: 29553313 DOI: 10.3201/eid2404.171509
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[h=1]Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans.[/h] Yamayoshi S, Kiso M, Yasuhara A, Ito M, Shu Y, Kawaoka Y.
[h=3]Abstract[/h] To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.
[h=4]KEYWORDS:[/h] H7N9; Highly pathogenic; PA; PB2; enhanced polymerase activity; influenza; respiratory infections; viruses
PMID: 29553313 DOI: 10.3201/eid2404.171509
Free full text