tetano
Editor, Senior Moderator
eNeurologicalSci
. 2021 Apr 18;100340.
doi: 10.1016/j.ensci.2021.100340. Online ahead of print.
Post-COVID seizure: A new feature of "long-COVID"
Keith J Kincaid[SUP] 1 [/SUP], Justin ChiKung[SUP] 1 [/SUP], Alexander J Senetar[SUP] 1 [/SUP], David Mendoza[SUP] 1 [/SUP], Daniel A Bonnin[SUP] 1 [/SUP], Windy L Purtlebaugh[SUP] 1 [/SUP], Rainier M Cabatbat[SUP] 2 [/SUP], Rondalyn Dickens[SUP] 1 [/SUP], Franklin D Echevarria[SUP] 1 [/SUP], Vidhu Kariyawasam[SUP] 1 [/SUP], Maria Bruzzone[SUP] 1 [/SUP], Alexis N Simpkins[SUP] 1 [/SUP]
Affiliations
Abstract
Novel coronavirus SARS-CoV-2 has created unprecedented healthcare challenges. Neurologic deficits are often an important presenting symptom. To date, the only reported post-infectious COVID-19 manifestations of neurologic disease include cognitive deficits and dysfunction of the peripheral nervous system. Here we report that seizure can also be a post-COVID-19 or "long-COVID" complication. We present a 71-year-old man with hypertension, diabetes mellitus, and COVID-19 diagnosed by RT-PCR who initially presented with posterior circulation stroke-like symptoms, which completely resolved after emergent thrombolysis. Six days later, the patient returned with seizure activity, supported by radiographic and electroencephalographic studies. Notably, he was negative for SARS-CoV-2, and no other provoking factor was uncovered after a comprehensive work-up. To our knowledge, this is the first report of post-infectious seizures after a case of COVID-19, highlighting the potential importance of monitoring for neurologic symptoms in COVID-19 patients, even after convalescence.
Keywords: COVID-19; Long-COVID; Post-infectious seizure; SARS-CoV-2; Seizure; Stroke.
. 2021 Apr 18;100340.
doi: 10.1016/j.ensci.2021.100340. Online ahead of print.
Post-COVID seizure: A new feature of "long-COVID"
Keith J Kincaid[SUP] 1 [/SUP], Justin ChiKung[SUP] 1 [/SUP], Alexander J Senetar[SUP] 1 [/SUP], David Mendoza[SUP] 1 [/SUP], Daniel A Bonnin[SUP] 1 [/SUP], Windy L Purtlebaugh[SUP] 1 [/SUP], Rainier M Cabatbat[SUP] 2 [/SUP], Rondalyn Dickens[SUP] 1 [/SUP], Franklin D Echevarria[SUP] 1 [/SUP], Vidhu Kariyawasam[SUP] 1 [/SUP], Maria Bruzzone[SUP] 1 [/SUP], Alexis N Simpkins[SUP] 1 [/SUP]
Affiliations
- PMID: 33898792
- PMCID: PMC8053221
- DOI: 10.1016/j.ensci.2021.100340
Abstract
Novel coronavirus SARS-CoV-2 has created unprecedented healthcare challenges. Neurologic deficits are often an important presenting symptom. To date, the only reported post-infectious COVID-19 manifestations of neurologic disease include cognitive deficits and dysfunction of the peripheral nervous system. Here we report that seizure can also be a post-COVID-19 or "long-COVID" complication. We present a 71-year-old man with hypertension, diabetes mellitus, and COVID-19 diagnosed by RT-PCR who initially presented with posterior circulation stroke-like symptoms, which completely resolved after emergent thrombolysis. Six days later, the patient returned with seizure activity, supported by radiographic and electroencephalographic studies. Notably, he was negative for SARS-CoV-2, and no other provoking factor was uncovered after a comprehensive work-up. To our knowledge, this is the first report of post-infectious seizures after a case of COVID-19, highlighting the potential importance of monitoring for neurologic symptoms in COVID-19 patients, even after convalescence.
Keywords: COVID-19; Long-COVID; Post-infectious seizure; SARS-CoV-2; Seizure; Stroke.