tetano
Editor, Senior Moderator
Endocrine
. 2021 Oct 30.
doi: 10.1007/s12020-021-02923-7. Online ahead of print.
Association of blood glucose level and prognosis of inpatients with coexistent diabetes and COVID-19
Weiwei Duan[SUP] #[/SUP][SUP] 1 2 3 4 [/SUP], Liangyu Li[SUP] #[/SUP][SUP] 5 6 [/SUP], Xuesong Li[SUP] #[/SUP][SUP] 7 [/SUP], Mengyan Zhu[SUP] #[/SUP][SUP] 5 6 [/SUP], Lingxiang Wu[SUP] 5 6 [/SUP], Wei Wu[SUP] 5 6 [/SUP], Kening Li[SUP] 5 6 [/SUP], Yuan Liang[SUP] 5 6 [/SUP], Rong Ding[SUP] 5 6 [/SUP], Wenhua You[SUP] 5 6 [/SUP], Ziyu Wang[SUP] 5 6 [/SUP], Bin Huang[SUP] 5 6 [/SUP], Min Wu[SUP] 5 6 [/SUP], Tingting Zhang[SUP] 5 6 [/SUP], Jie Li[SUP] 5 6 [/SUP], Yan Li[SUP] 5 6 [/SUP], Jiaofang Shao[SUP] 5 6 [/SUP], Changsong Lin[SUP] 5 6 [/SUP], Pengping Li[SUP] 5 6 [/SUP], Qianghu Wang[SUP] 5 6 8 9 [/SUP], Shukui Wang[SUP] 10 [/SUP], Xinyi Xia[SUP] 11 12 [/SUP], Yu Liu[SUP] 13 [/SUP], Sali Lyu[SUP] 14 15 16 17 [/SUP]
Affiliations
Abstract
Type 2 diabetes (T2D) increases the risk of coronavirus disease (COVID-19). This study investigates the association between glucose control of COVID-19 patients with T2D in first 7 days after hospital admission and prognosis. A total of 252 infected inpatients with T2D in China were included. Well-controlled blood glucose was defined as stable fasting blood glucose (FBG) levels in the range of 3.9-7.8 mmol/L during first 7 days using indicators of average (FBG[SUB]A[/SUB]), maximum (FBG[SUB]M[/SUB]) or first-time (FBG[SUB]1[/SUB]) FBG levels. The primary endpoint was admission to intensive care unit or death. Hazard ratio (HR) of poorly controlled glucose level group compared with well-controlled group were 4.96 (P = 0.021) for FBG[SUB]M[/SUB] and 5.55 (P = 0.014) for FBG[SUB]A[/SUB]. Well-controlled blood glucose levels in first 7 days could improve the prognosis of COVID-19 inpatients with diabetes.
Keywords: COVID-19; Glucose control; Prognosis analysis; Type 2 diabetes.
. 2021 Oct 30.
doi: 10.1007/s12020-021-02923-7. Online ahead of print.
Association of blood glucose level and prognosis of inpatients with coexistent diabetes and COVID-19
Weiwei Duan[SUP] #[/SUP][SUP] 1 2 3 4 [/SUP], Liangyu Li[SUP] #[/SUP][SUP] 5 6 [/SUP], Xuesong Li[SUP] #[/SUP][SUP] 7 [/SUP], Mengyan Zhu[SUP] #[/SUP][SUP] 5 6 [/SUP], Lingxiang Wu[SUP] 5 6 [/SUP], Wei Wu[SUP] 5 6 [/SUP], Kening Li[SUP] 5 6 [/SUP], Yuan Liang[SUP] 5 6 [/SUP], Rong Ding[SUP] 5 6 [/SUP], Wenhua You[SUP] 5 6 [/SUP], Ziyu Wang[SUP] 5 6 [/SUP], Bin Huang[SUP] 5 6 [/SUP], Min Wu[SUP] 5 6 [/SUP], Tingting Zhang[SUP] 5 6 [/SUP], Jie Li[SUP] 5 6 [/SUP], Yan Li[SUP] 5 6 [/SUP], Jiaofang Shao[SUP] 5 6 [/SUP], Changsong Lin[SUP] 5 6 [/SUP], Pengping Li[SUP] 5 6 [/SUP], Qianghu Wang[SUP] 5 6 8 9 [/SUP], Shukui Wang[SUP] 10 [/SUP], Xinyi Xia[SUP] 11 12 [/SUP], Yu Liu[SUP] 13 [/SUP], Sali Lyu[SUP] 14 15 16 17 [/SUP]
Affiliations
- PMID: 34716852
- DOI: 10.1007/s12020-021-02923-7
Abstract
Type 2 diabetes (T2D) increases the risk of coronavirus disease (COVID-19). This study investigates the association between glucose control of COVID-19 patients with T2D in first 7 days after hospital admission and prognosis. A total of 252 infected inpatients with T2D in China were included. Well-controlled blood glucose was defined as stable fasting blood glucose (FBG) levels in the range of 3.9-7.8 mmol/L during first 7 days using indicators of average (FBG[SUB]A[/SUB]), maximum (FBG[SUB]M[/SUB]) or first-time (FBG[SUB]1[/SUB]) FBG levels. The primary endpoint was admission to intensive care unit or death. Hazard ratio (HR) of poorly controlled glucose level group compared with well-controlled group were 4.96 (P = 0.021) for FBG[SUB]M[/SUB] and 5.55 (P = 0.014) for FBG[SUB]A[/SUB]. Well-controlled blood glucose levels in first 7 days could improve the prognosis of COVID-19 inpatients with diabetes.
Keywords: COVID-19; Glucose control; Prognosis analysis; Type 2 diabetes.