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Emerging Invasive Group A Streptococcus M1UK Lineage Detected by Allele-Specific PCR, England, 20201

Mary Wilson

Well-known member
May 2023

DOI: 10.3201/eid2905.221887

Xiangyun Zhi, Ho Kwong Li, Hanqi Li, Zuzanna Loboda, Samson Charles, Ana Vieira, Kristin Huse, Elita Jauneikaite, Lucy Reeves, Kai Yi Mok, Juliana Coelho, Theresa Lamagni, and Shiranee Sriskandan

Abstract

Increasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage M1[SUB]UK[/SUB]. An allele-specific PCR was developed to distinguish M1[SUB]UK[/SUB] from other emm1 strains. The M1[SUB]UK[/SUB] lineage represented 91% of invasive emm1 isolates in England in 2020. Allele-specific PCR will permit surveillance for M1[SUB]UK[/SUB] without need for genome sequencing.

https://wwwnc.cdc.gov/eid/article/29/5/22-1887_article#suggestedcitation
 
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