tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2022 Dec 30;2164219.
doi: 10.1080/22221751.2022.2164219. Online ahead of print.
The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development
Haiyun Yu[SUP] 1 [/SUP], Fei Guan[SUP] 1 [/SUP], Heather Miller[SUP] 2 [/SUP], Jiahui Lei[SUP] 1 [/SUP], Chaohong Liu[SUP] 1 [/SUP]
Affiliations
Abstract
ABSTRACTThe coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly. There is accumulating evidence indicating that the nucleocapsid protein is multi-functional, playing a key role in the pathogenesis of COVID-19 and antiviral immunity against SARS-CoV-2. Here, we summarize its potential application in the prevention of COVID-19, which is based on its role in inflammation, cell death, antiviral innate immunity, and antiviral adapted immunity.
Keywords: Adapted immunity; Cell death; Inflammation; Innate immunity; Nucleocapsid; SARS-CoV-2; Vaccine.
. 2022 Dec 30;2164219.
doi: 10.1080/22221751.2022.2164219. Online ahead of print.
The role of SARS-CoV-2 nucleocapsid protein in antiviral immunity and vaccine development
Haiyun Yu[SUP] 1 [/SUP], Fei Guan[SUP] 1 [/SUP], Heather Miller[SUP] 2 [/SUP], Jiahui Lei[SUP] 1 [/SUP], Chaohong Liu[SUP] 1 [/SUP]
Affiliations
- PMID: 36583642
- DOI: 10.1080/22221751.2022.2164219
Abstract
ABSTRACTThe coronavirus disease 2019 (COVID-19) has caused enormous health risks and global economic disruption. This disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 nucleocapsid protein is a structural protein involved in viral replication and assembly. There is accumulating evidence indicating that the nucleocapsid protein is multi-functional, playing a key role in the pathogenesis of COVID-19 and antiviral immunity against SARS-CoV-2. Here, we summarize its potential application in the prevention of COVID-19, which is based on its role in inflammation, cell death, antiviral innate immunity, and antiviral adapted immunity.
Keywords: Adapted immunity; Cell death; Inflammation; Innate immunity; Nucleocapsid; SARS-CoV-2; Vaccine.