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Emerg Microbes Infect . Neutralizing activity against bovine H5N1 HPAIV (clade 2.3.4.4b) in human plasma after seasonal influenza vaccination

tetano

tetano

Editor, Senior Moderator
Emerg Microbes Infect


. 2025 Jul 1:2528539.
doi: 10.1080/22221751.2025.2528539. Online ahead of print. Neutralizing activity against bovine H5N1 HPAIV (clade 2.3.4.4b) in human plasma after seasonal influenza vaccination

Lu Zhang[SUP] 1 2 [/SUP], Georg M N Behrens[SUP] 3 4 5 [/SUP], Amy Kempf[SUP] 1 2 [/SUP], Inga Nehlmeier[SUP] 1 [/SUP], Sabine Gärtner[SUP] 1 [/SUP], Anna-Sophie Moldenhauer[SUP] 1 [/SUP], Luise Graichen[SUP] 1 [/SUP], Christine Happle[SUP] 3 5 6 [/SUP], Michael Winkler[SUP] 1 2 [/SUP], Alexandra Dopfer-Jablonka[SUP] 3 4 [/SUP], Stefan Pöhlmann[SUP] 1 2 [/SUP], Markus Hoffmann[SUP] 1 2 [/SUP]



Affiliations
No abstract available
​
 
from above:


"We report that bovine H5N1 HPAIV exhibits a cell line tropism similar to other H5Ny HPAIV and is inhibited by IFITM proteins. Moreover, we provide evidence that seasonal influenza vaccines induce cross-neutralizing antibodies against bovine H5N1 HPAIV. While our results await confirmation with authentic virus, our findings align with a study by Gioia et al., demonstrating that seasonal influenza vaccines induce neutralizing antibodies against clade 3 H5N1 HPAIV [16]. Additionally, Sanz-Muñoz et al. obtained evidence for the existence of low level basal heterosubtypic immunity against H5N1 HPAIV subtypes in humans that could be increased by seasonal influenza vaccination using a recombinant H1N1 influenza virus expressing HA and NA proteins of H5N1 HPAIV A/chicken/Egypt/F71-F114C/2022 (clade 2.3.4.4b) [17] – however, bovine H5N1 HPAIV was not tested. Collectively, our results suggest that the innate immune system imposes a barrier against bovine H5N1 HPAIV infection and that seasonal influenza vaccines induce cross-neutralizing activity against bovine H5N1 HPAIV. Whether this cross-neutralization can protect humans against infection by bovine H5N1 HPAIV and/or severe disease development requires further research." ​
 
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