tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2025 Sep 9:2558881.
doi: 10.1080/22221751.2025.2558881. Online ahead of print. Matrix Protein 1 (M1) of Influenza A Virus: Structural and Functional Insights
Yanting Zhu[SUP] 1 [/SUP], Yixue Sun[SUP] 2 [/SUP], Xiaoyu Deng[SUP] 3 [/SUP], Peige Cao[SUP] 1 [/SUP], Siqi Li[SUP] 1 [/SUP], Huilin Yu[SUP] 4 [/SUP], Shouzhi Sheng[SUP] 1 [/SUP], Yanlong Cong[SUP] 1 [/SUP]
Affiliations
Enveloped viruses rely on matrix proteins for structural integrity and lifecycle progression. Matrix protein 1 (M1) is the most abundant structural protein of influenza A virus (IAV), playing a multifaceted role in viral uncoating, polymerase activity, vRNA transcription and replication, and assembly and budding. The M1 protein not only interacts with host cells but also regulates viral morphogenesis, thereby influencing viral transmissibility and pathogenicity. These properties make it a highly promising antiviral target. This review elucidates the intricate structure and function of M1, highlighting its regulatory influence on IAV replication and adaptation, and providing critical insights into viral replication dynamics and epidemiological shifts.Beyond engaging host factors, the M1 protein orchestrates virion morphogenesis-thereby shaping viral transmissibility and pathogenicity-making it a highly attractive antiviral target.
Keywords: antiviral target; influenza A virus; matrix protein 1; viral lifecycle.
. 2025 Sep 9:2558881.
doi: 10.1080/22221751.2025.2558881. Online ahead of print. Matrix Protein 1 (M1) of Influenza A Virus: Structural and Functional Insights
Yanting Zhu[SUP] 1 [/SUP], Yixue Sun[SUP] 2 [/SUP], Xiaoyu Deng[SUP] 3 [/SUP], Peige Cao[SUP] 1 [/SUP], Siqi Li[SUP] 1 [/SUP], Huilin Yu[SUP] 4 [/SUP], Shouzhi Sheng[SUP] 1 [/SUP], Yanlong Cong[SUP] 1 [/SUP]
Affiliations
- PMID: 40925098
- DOI: 10.1080/22221751.2025.2558881
Enveloped viruses rely on matrix proteins for structural integrity and lifecycle progression. Matrix protein 1 (M1) is the most abundant structural protein of influenza A virus (IAV), playing a multifaceted role in viral uncoating, polymerase activity, vRNA transcription and replication, and assembly and budding. The M1 protein not only interacts with host cells but also regulates viral morphogenesis, thereby influencing viral transmissibility and pathogenicity. These properties make it a highly promising antiviral target. This review elucidates the intricate structure and function of M1, highlighting its regulatory influence on IAV replication and adaptation, and providing critical insights into viral replication dynamics and epidemiological shifts.Beyond engaging host factors, the M1 protein orchestrates virion morphogenesis-thereby shaping viral transmissibility and pathogenicity-making it a highly attractive antiviral target.
Keywords: antiviral target; influenza A virus; matrix protein 1; viral lifecycle.