tetano
Editor, Senior Moderator
Emerg Microbes Infect. 2020 Dec;9(1):469-473. doi: 10.1080/22221751.2020.1732837. [h=1]Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.[/h]
Chen W[SUP]1[/SUP], Lan Y[SUP]1[/SUP], Yuan X[SUP]1[/SUP], Deng X[SUP]1[/SUP], Li Y[SUP]1[/SUP], Cai X[SUP]1[/SUP], Li L[SUP]1[/SUP], He R[SUP]1[/SUP], Tan Y[SUP]1[/SUP], Deng X[SUP]1[/SUP], Gao M[SUP]1[/SUP], Tang G[SUP]1[/SUP], Zhao L[SUP]1[/SUP], Wang J[SUP]1[/SUP], Fan Q[SUP]1[/SUP], Wen C[SUP]1[/SUP], Tong Y[SUP]1[/SUP], Tang Y[SUP]1[/SUP], Hu F[SUP]1[/SUP], Li F[SUP]1[/SUP], Tang X[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
[h=4]KEYWORDS:[/h] 2019-ncov; anal swab; blood viral RNA; laboratory test; pharyngeal swab
PMID: 32102625 DOI: 10.1080/22221751.2020.1732837
Chen W[SUP]1[/SUP], Lan Y[SUP]1[/SUP], Yuan X[SUP]1[/SUP], Deng X[SUP]1[/SUP], Li Y[SUP]1[/SUP], Cai X[SUP]1[/SUP], Li L[SUP]1[/SUP], He R[SUP]1[/SUP], Tan Y[SUP]1[/SUP], Deng X[SUP]1[/SUP], Gao M[SUP]1[/SUP], Tang G[SUP]1[/SUP], Zhao L[SUP]1[/SUP], Wang J[SUP]1[/SUP], Fan Q[SUP]1[/SUP], Wen C[SUP]1[/SUP], Tong Y[SUP]1[/SUP], Tang Y[SUP]1[/SUP], Hu F[SUP]1[/SUP], Li F[SUP]1[/SUP], Tang X[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
[h=4]KEYWORDS:[/h] 2019-ncov; anal swab; blood viral RNA; laboratory test; pharyngeal swab
PMID: 32102625 DOI: 10.1080/22221751.2020.1732837