tetano
Editor, Senior Moderator
Emerg Microbes Infect
. 2022 Apr 22;1-29.
doi: 10.1080/22221751.2022.2069515. Online ahead of print.
Assessing Potential Pathogenicity of Novel Highly Pathogenic Avian Influenza (H5N6) Viruses Isolated from Mongolian Wild Duck Feces Using a Mouse Model
Bao Tuan Duong[SUP] 1 [/SUP], Duc Duong Than[SUP] 1 [/SUP], Ulaankhuu Ankhanbaatar[SUP] 2 [/SUP], Delgerzul Gombo-Ochir[SUP] 2 [/SUP], Gansukh Shura[SUP] 2 [/SUP], Amartuvshin Tsolmon[SUP] 2 [/SUP], Ganzorig Basan[SUP] 2 [/SUP], Seon Ju Yeo[SUP] 3 [/SUP], Hyun Park[SUP] 1 [/SUP]
Affiliations
Abstract
Several novel highly pathogenic avian influenza (HPAIVs) A(H5N6) viruses were reported in Mongolia in 2020, some of which included host-specific markers associated with mammalian infection. However, their pathogenicity has not yet been investigated. Here, we isolated and evaluate two novel genotypes of A(H5N6) subtype in Mongolia during 2018-19 (A/wildDuck/MN/H5N6/2018-19). Their evolution pattern and molecular characteristics were evaluated using gene sequencing and their pathogenicity was determined using a mouse model. We also compared their antigenicity with previous H5 Clade 2.3.4.4 human isolates by cross-hemagglutination inhibition (HI). Our data suggests that A/wildDuck/MN/H5N6/2018-19 belongs to clade 2.3.4.4h, and maintains several residues associated with mammal adaptation. In addition, our evaluations revealed that their isolates are less virulent in mice than the previously identified H5 human isolates. However, their antigenicity is distinct from other HPAIVs H5 clade 2.3.4.4, thus supporting their continued evaluation as potential infection risks and the preparation of novel candidate vaccines for their neutralization.
Keywords: 2.3.4.4h; Avian influenza viruses; H5N6; Hemagglutination inhibition; Mongolia.
. 2022 Apr 22;1-29.
doi: 10.1080/22221751.2022.2069515. Online ahead of print.
Assessing Potential Pathogenicity of Novel Highly Pathogenic Avian Influenza (H5N6) Viruses Isolated from Mongolian Wild Duck Feces Using a Mouse Model
Bao Tuan Duong[SUP] 1 [/SUP], Duc Duong Than[SUP] 1 [/SUP], Ulaankhuu Ankhanbaatar[SUP] 2 [/SUP], Delgerzul Gombo-Ochir[SUP] 2 [/SUP], Gansukh Shura[SUP] 2 [/SUP], Amartuvshin Tsolmon[SUP] 2 [/SUP], Ganzorig Basan[SUP] 2 [/SUP], Seon Ju Yeo[SUP] 3 [/SUP], Hyun Park[SUP] 1 [/SUP]
Affiliations
- PMID: 35451353
- DOI: 10.1080/22221751.2022.2069515
Abstract
Several novel highly pathogenic avian influenza (HPAIVs) A(H5N6) viruses were reported in Mongolia in 2020, some of which included host-specific markers associated with mammalian infection. However, their pathogenicity has not yet been investigated. Here, we isolated and evaluate two novel genotypes of A(H5N6) subtype in Mongolia during 2018-19 (A/wildDuck/MN/H5N6/2018-19). Their evolution pattern and molecular characteristics were evaluated using gene sequencing and their pathogenicity was determined using a mouse model. We also compared their antigenicity with previous H5 Clade 2.3.4.4 human isolates by cross-hemagglutination inhibition (HI). Our data suggests that A/wildDuck/MN/H5N6/2018-19 belongs to clade 2.3.4.4h, and maintains several residues associated with mammal adaptation. In addition, our evaluations revealed that their isolates are less virulent in mice than the previously identified H5 human isolates. However, their antigenicity is distinct from other HPAIVs H5 clade 2.3.4.4, thus supporting their continued evaluation as potential infection risks and the preparation of novel candidate vaccines for their neutralization.
Keywords: 2.3.4.4h; Avian influenza viruses; H5N6; Hemagglutination inhibition; Mongolia.