tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Aug 5;27(10).
doi: 10.3201/eid2710.211509. Online ahead of print.
SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy
Aurélie Truffot, Julien Andréani, Marion Le Maréchal, Alban Caporossi, Olivier Epaulard, Raphaele Germi, Pascal Poignard, Sylvie Larrat
Abstract
A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emergence of spike receptor binding domain mutations was found, associated with a compartmentalization of viral populations.
Keywords: COVID-19; SARS-CoV-2; bamlanivimab; compartmentalization; coronavirus disease; coronaviruses; immunotherapy; monoclonal antibody; monotherapy; respiratory infections; selection; severe acute respiratory syndrome coronavirus 2; variants; viruses; whole-genome sequencing; zoonoses.
. 2021 Aug 5;27(10).
doi: 10.3201/eid2710.211509. Online ahead of print.
SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy
Aurélie Truffot, Julien Andréani, Marion Le Maréchal, Alban Caporossi, Olivier Epaulard, Raphaele Germi, Pascal Poignard, Sylvie Larrat
- PMID: 34352197
- DOI: 10.3201/eid2710.211509
Abstract
A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emergence of spike receptor binding domain mutations was found, associated with a compartmentalization of viral populations.
Keywords: COVID-19; SARS-CoV-2; bamlanivimab; compartmentalization; coronavirus disease; coronaviruses; immunotherapy; monoclonal antibody; monotherapy; respiratory infections; selection; severe acute respiratory syndrome coronavirus 2; variants; viruses; whole-genome sequencing; zoonoses.