Giuseppe
Emeritus
Abstract. Oseltamivir-Resistant Influenza Viruses A (H1N1), Norway, 2007?08 (Emerg Infect Dis, edited)
DOI: 10.3201/eid1502.081031
Suggested citation for this article: Hauge SH, Dudman S, Borgen K, Lackenby A, Hungnes O. Oseltamivir-resistant influenza viruses A (H1N1), Norway, 2007?08. Emerg Infect Dis. 2009 Feb; [Epub ahead of print]
[Original Full Document: LINK. EDITED.]
Oseltamivir-Resistant Influenza Viruses A (H1N1), Norway, 2007?08
Siri H. Hauge, Susanne Dudman, Katrine Borgen, Angie Lackenby, and Olav Hungnes
Author affiliations: Norwegian Institute of Public Health, Oslo, Norway (S.H. Hauge, S. Dudman, K. Borgen, O. Hungnes); and Health Protection Agency, London, UK (A. Lackenby)
In Norway in January 2008, unprecedented levels of oseltamivir resistance were found in 12/16 influenza viruses A (H1N1) tested. To investigate the epidemiologic and clinical characteristics of these viruses, we used sequence analysis to test all available subtype H1N1 viruses from the 2007?08 season for resistance. Questionnaires from physicians provided information on predisposing diseases, oseltamivir use, symptoms, and complications. Clinical data were obtained for 265 patients. In total, 183 (67.3%) of 272 viruses were oseltamivir resistant. Resistance was not associated with prior use of antiviral drugs. Symptoms and hospitalization rates did not differ for patients infected with a resistant or a susceptible virus. Oseltamivir-resistant influenza viruses A (H1N1) did not show diminished capability to spread in the absence of selective pressure. The ability of these viruses to sustain their fitness and spread among persons should be considered when shaping future strategies for treating and preventing seasonal and pandemic influenza.
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DOI: 10.3201/eid1502.081031
Suggested citation for this article: Hauge SH, Dudman S, Borgen K, Lackenby A, Hungnes O. Oseltamivir-resistant influenza viruses A (H1N1), Norway, 2007?08. Emerg Infect Dis. 2009 Feb; [Epub ahead of print]
[Original Full Document: LINK. EDITED.]
Oseltamivir-Resistant Influenza Viruses A (H1N1), Norway, 2007?08
Siri H. Hauge, Susanne Dudman, Katrine Borgen, Angie Lackenby, and Olav Hungnes
Author affiliations: Norwegian Institute of Public Health, Oslo, Norway (S.H. Hauge, S. Dudman, K. Borgen, O. Hungnes); and Health Protection Agency, London, UK (A. Lackenby)
In Norway in January 2008, unprecedented levels of oseltamivir resistance were found in 12/16 influenza viruses A (H1N1) tested. To investigate the epidemiologic and clinical characteristics of these viruses, we used sequence analysis to test all available subtype H1N1 viruses from the 2007?08 season for resistance. Questionnaires from physicians provided information on predisposing diseases, oseltamivir use, symptoms, and complications. Clinical data were obtained for 265 patients. In total, 183 (67.3%) of 272 viruses were oseltamivir resistant. Resistance was not associated with prior use of antiviral drugs. Symptoms and hospitalization rates did not differ for patients infected with a resistant or a susceptible virus. Oseltamivir-resistant influenza viruses A (H1N1) did not show diminished capability to spread in the absence of selective pressure. The ability of these viruses to sustain their fitness and spread among persons should be considered when shaping future strategies for treating and preventing seasonal and pandemic influenza.
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