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Emerg Infect Dis . MERS-CoV‒Specific T-Cell Responses in Camels after Single MVA-MERS-S Vaccination

tetano

tetano

Editor, Senior Moderator
Emerg Infect Dis


. 2023 Jun;29(6):1236-1239.
doi: 10.3201/eid2906.230128.
MERS-CoV‒Specific T-Cell Responses in Camels after Single MVA-MERS-S Vaccination

Christian Meyer Zu Natrup, Lisa-Marie Schünemann, Giulietta Saletti, Sabrina Clever, Vanessa Herder, Sunitha Joseph, Marina Rodriguez, Ulrich Wernery, Gerd Sutter, Asisa Volz
Abstract

We developed an ELISPOT assay for evaluating Middle East respiratory syndrome coronavirus (MERS-CoV)‒specific T-cell responses in dromedary camels. After single modified vaccinia virus Ankara-MERS-S vaccination, seropositive camels showed increased levels of MERS-CoV‒specific T cells and antibodies, indicating suitability of camel vaccinations in disease-endemic areas as a promising approach to control infection.

Keywords: Dubai; ELISPOT assay; MERS-CoV; MVA; MVA expressing full-length MERS-CoV spike protein as antigen; MVA-MERS-S; Middle East respiratory syndrome coronavirus; T-cell responses; coronavirus; dromedary camels; modified vaccinia virus Ankara; respiratory infections; spike protein; vaccination; viruses; zoonoses.
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