tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2022 Jul 22;28(9).
doi: 10.3201/eid2809.220729. Online ahead of print.
Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies
Michael Loesche, Elizabeth W Karlson, Opeyemi Talabi, Guohai Zhou, Natalie Boutin, Rachel Atchley, Gideon Loevinsohn, Jun Bai Park Chang, Mohammad A Hasdianda, Adetoun Okenla, Elizabeth Sampson, Haley Schram, Karen Magsipoc, Kirsten Goodman, Lauren Donahue, Maureen MacGowan, Lewis A Novack, Petr Jarolim, Lindsey R Baden, Eric J Nilles
Abstract
Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies.
Keywords: COVID-19; SARS-CoV-2; coronavirus disease; coronaviruses; kinetics; longitudinal; nucleocapsid antibody; respiratory infections; seroepidemiology; seroreversion; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.
. 2022 Jul 22;28(9).
doi: 10.3201/eid2809.220729. Online ahead of print.
Longitudinal SARS-CoV-2 Nucleocapsid Antibody Kinetics, Seroreversion, and Implications for Seroepidemiologic Studies
Michael Loesche, Elizabeth W Karlson, Opeyemi Talabi, Guohai Zhou, Natalie Boutin, Rachel Atchley, Gideon Loevinsohn, Jun Bai Park Chang, Mohammad A Hasdianda, Adetoun Okenla, Elizabeth Sampson, Haley Schram, Karen Magsipoc, Kirsten Goodman, Lauren Donahue, Maureen MacGowan, Lewis A Novack, Petr Jarolim, Lindsey R Baden, Eric J Nilles
- PMID: 35868337
- DOI: 10.3201/eid2809.220729
Abstract
Given widespread use of spike antibody in generating coronavirus disease vaccines, SARS-CoV-2 nucleocapsid antibodies are increasingly used to indicate previous infection in serologic surveys. However, longitudinal kinetics and seroreversion are poorly defined. We found substantial seroreversion of nucleocapsid total immunoglobulin, underscoring the need to account for seroreversion in seroepidemiologic studies.
Keywords: COVID-19; SARS-CoV-2; coronavirus disease; coronaviruses; kinetics; longitudinal; nucleocapsid antibody; respiratory infections; seroepidemiology; seroreversion; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.