tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2020 Nov 13;27(2).
doi: 10.3201/eid2702.203824. Online ahead of print.
Intrauterine Transmission of SARS-CoV-2
Emanuele T S Stonoga, Laura de Almeida Lanzoni, Patricia Zadorosnei Rebutini, Andr? Luiz Permegiani de Oliveira, Jullie Anne Chiste, Cyllian Arias Fuga?a, Daniele M M Pr?, Ana Paula Percicote, Andrea Rossoni, Meri Bordignon Nogueira, Lucia de Noronha, Sonia Mara Raboni
Abstract
We documented fetal death associated with intrauterine transmission of severe acute respiratory syndrome coronavirus 2. We found chronic histiocytic intervillositis, maternal and fetal vascular malperfusion, microglial hyperplasia, and lymphocytic infiltrate in muscle in the placenta and fetal tissue. Placenta and umbilical cord blood tested positive for the virus by PCR, confirming transplacental transmission.
Keywords: 2019 novel coronavirus disease; Brazil; COVID-19; RT-PCR; SARS-CoV-2; autopsy; congenital transmission; coronavirus; coronavirus disease; diagnosis; intrauterine transmission; placenta; pregnancy; respiratory infections; saliva; severe acute respiratory syndrome coronavirus 2; stillbirth; swabs; testing; upper respiratory swab samples; viruses; zoonoses.
. 2020 Nov 13;27(2).
doi: 10.3201/eid2702.203824. Online ahead of print.
Intrauterine Transmission of SARS-CoV-2
Emanuele T S Stonoga, Laura de Almeida Lanzoni, Patricia Zadorosnei Rebutini, Andr? Luiz Permegiani de Oliveira, Jullie Anne Chiste, Cyllian Arias Fuga?a, Daniele M M Pr?, Ana Paula Percicote, Andrea Rossoni, Meri Bordignon Nogueira, Lucia de Noronha, Sonia Mara Raboni
- PMID: 33185524
- DOI: 10.3201/eid2702.203824
Abstract
We documented fetal death associated with intrauterine transmission of severe acute respiratory syndrome coronavirus 2. We found chronic histiocytic intervillositis, maternal and fetal vascular malperfusion, microglial hyperplasia, and lymphocytic infiltrate in muscle in the placenta and fetal tissue. Placenta and umbilical cord blood tested positive for the virus by PCR, confirming transplacental transmission.
Keywords: 2019 novel coronavirus disease; Brazil; COVID-19; RT-PCR; SARS-CoV-2; autopsy; congenital transmission; coronavirus; coronavirus disease; diagnosis; intrauterine transmission; placenta; pregnancy; respiratory infections; saliva; severe acute respiratory syndrome coronavirus 2; stillbirth; swabs; testing; upper respiratory swab samples; viruses; zoonoses.