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Emerg Infect Dis . Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

tetano

Editor, Senior Moderator
Emerg Infect Dis


. 2021 Jul 27;27(10).
doi: 10.3201/eid2710.211538. Online ahead of print.
Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

Daniele Focosi, Federica Novazzi, Angelo Genoni, Francesco Dentali, Daniela Dalla Gasperina, Andreina Baj, Fabrizio Maggi

Abstract

We report in vivo selection of a severe acute respiratory syndrome coronavirus 2 spike mutation (Q493R) conferring simultaneous resistance to bamlanivimab and etesivimab. This mutation was isolated from a patient who had coronavirus disease and was treated with these drugs.

Keywords: COVID-19; Italy; SARS-CoV-2; bamlaniv/etesevimab; coronavirus disease; coronaviruses; receptor-binding motif; respiratory infections; severe acute respiratory syndrome coronavirus 2; spike protein; spike protein escape mutation Q493R; treatment; variant; viruses; zoonoses.
 
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