tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2020 Jul 30;26(12).
doi: 10.3201/eid2612.202308. Online ahead of print.
Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
Susanna K P Lau, Antonio C P Wong, Hayes K H Luk, Kenneth S M Li, Joshua Fung, Zirong He, Flora K K Cheng, Tony T Y Chan, Stella Chu, Kam Leng Aw-Yong, Terrence C K Lau, Kitty S C Fung, Patrick C Y Woo
Abstract
Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
Keywords: COVID-19; SARS; SARS-CoV-2; SARS-related coronavirus; bat; coronavirus disease; origin; respiratory infections; severe acute respiratory syndrome; severe acute respiratory syndrome coronavirus 2; tropism; viruses; zoonoses.
. 2020 Jul 30;26(12).
doi: 10.3201/eid2612.202308. Online ahead of print.
Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells
Susanna K P Lau, Antonio C P Wong, Hayes K H Luk, Kenneth S M Li, Joshua Fung, Zirong He, Flora K K Cheng, Tony T Y Chan, Stella Chu, Kam Leng Aw-Yong, Terrence C K Lau, Kitty S C Fung, Patrick C Y Woo
- PMID: 32730733
- DOI: 10.3201/eid2612.202308
Abstract
Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
Keywords: COVID-19; SARS; SARS-CoV-2; SARS-related coronavirus; bat; coronavirus disease; origin; respiratory infections; severe acute respiratory syndrome; severe acute respiratory syndrome coronavirus 2; tropism; viruses; zoonoses.