tetano
Editor, Senior Moderator
Emerg Infect Dis
. 2021 Jun 8;27(8).
doi: 10.3201/eid2708.211145. Online ahead of print.
Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany
Tatjana Schwarz, Pinkus Tober-Lau, David Hillus, Elisa T Helbig, Lena J Lippert, Charlotte Thibeault, Willi Koch, Irmgard Landgraf, Janine Michel, Leon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Chantip Dang-Heine, Stefanie Kasper, Friederike Münn, Kai Kappert, Andreas Nitsche, Rudolf Tauber, Sein Schmidt, Piotr Kopankiewicz, Harald Bias, Joachim Seybold, Christof von Kalle, Terry C Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander, Victor M Corman, Florian Kurth
Abstract
We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.
Keywords: B cell; Berlin; COVID-19; Germany; SARS-CoV-2; T cell; antibody; coronavirus disease; immunity; mRNA; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine; viruses; zoonoses.
. 2021 Jun 8;27(8).
doi: 10.3201/eid2708.211145. Online ahead of print.
Delayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany
Tatjana Schwarz, Pinkus Tober-Lau, David Hillus, Elisa T Helbig, Lena J Lippert, Charlotte Thibeault, Willi Koch, Irmgard Landgraf, Janine Michel, Leon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Chantip Dang-Heine, Stefanie Kasper, Friederike Münn, Kai Kappert, Andreas Nitsche, Rudolf Tauber, Sein Schmidt, Piotr Kopankiewicz, Harald Bias, Joachim Seybold, Christof von Kalle, Terry C Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander, Victor M Corman, Florian Kurth
- PMID: 34102097
- DOI: 10.3201/eid2708.211145
Abstract
We detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize that nonpharmaceutical interventions for coronavirus disease remain crucial and that additional immunizations for the elderly might become necessary.
Keywords: B cell; Berlin; COVID-19; Germany; SARS-CoV-2; T cell; antibody; coronavirus disease; immunity; mRNA; respiratory infections; severe acute respiratory syndrome coronavirus 2; vaccine; viruses; zoonoses.