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EMBO J . SARS-CoV-2 variants as super cell fusers: cause or consequence of COVID-19 severity?

tetano

Editor, Senior Moderator
EMBO J


. 2021 Nov 15;e110041.
doi: 10.15252/embj.2021110041. Online ahead of print.
SARS-CoV-2 variants as super cell fusers: cause or consequence of COVID-19 severity?


Jana Koch[SUP] 1 2 [/SUP], Zina M Uckeley[SUP] 1 2 [/SUP], Pierre-Yves Lozach[SUP] 1 2 3 [/SUP]



Affiliations

Abstract

The most severe forms of coronavirus disease 2019 (COVID-19) are often associated with the presence of syncytia in the lungs resulting from cell-cell fusion mediated by the SARS-CoV-2 spike protein. In this issue, Rajah and colleagues show that the SARS-CoV-2 alpha, beta, and delta variants promote enhanced syncytia formation as compared to the original strain.
 
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