tetano
Editor, Senior Moderator
Understanding global influenza migration and per sistence is crucial for vaccine strain selection. Using 240
new human influenza A virus whole genomes collected
in Vietnam during 2001?2008, we looked for persistence
patterns and migratory connections between Vietnam and
other countries. We found that viruses in Vietnam migrate
to and from China, Hong Kong, Taiwan, Cambodia, Japan, South Korea, and the United States. We attempted
to reduce geographic bias by generating phylogenies
subsampled at the year and country levels. However,
migration events in these phylogenies were still driven
by the presence or absence of sequence data, indicating that an epidemiologic study design that controls for
prevalence is required for robust migration analysis. With
whole-genome data, most migration events are not detectable from the phylogeny of the hemagglutinin segment
alone, although general migratory relationships between
Vietnam and other countries are visible in the hemagglutinin phylogeny. It is possible that virus lineages in Vietnam
persisted for >1 year
full article
http://wwwnc.cdc.gov/eid/article/19/11/pdfs/13-0349.pdf
new human influenza A virus whole genomes collected
in Vietnam during 2001?2008, we looked for persistence
patterns and migratory connections between Vietnam and
other countries. We found that viruses in Vietnam migrate
to and from China, Hong Kong, Taiwan, Cambodia, Japan, South Korea, and the United States. We attempted
to reduce geographic bias by generating phylogenies
subsampled at the year and country levels. However,
migration events in these phylogenies were still driven
by the presence or absence of sequence data, indicating that an epidemiologic study design that controls for
prevalence is required for robust migration analysis. With
whole-genome data, most migration events are not detectable from the phylogeny of the hemagglutinin segment
alone, although general migratory relationships between
Vietnam and other countries are visible in the hemagglutinin phylogeny. It is possible that virus lineages in Vietnam
persisted for >1 year
full article
http://wwwnc.cdc.gov/eid/article/19/11/pdfs/13-0349.pdf