Mary Wilson
Well-known member
Published: 13 July 2024
https://doi.org/10.1093/ofid/ofae397
Nicole Tang, Jue Tao Lim, PhD, Borame Dickens, PhD, Calvin Chiew, MPH, Lee Ching Ng, PhD, Po Ying Chia, PhD, Yee Sin Leo, MPH, David Chien Lye, MBBS, Kelvin Bryan Tan, PhD, Liang En Wee, MPH
Abstract
Background and Aims
Elucidating whether prior dengue potentially confers cross-protection against COVID-19 is of public health importance in tropical countries at-risk of overlapping dengue and COVID-19 epidemics. However, studies to-date have yielded conflicting results. We aimed to assess effects of recent prior dengue infection on risk and severity of subsequent SARS-CoV-2 infection amongst adult Singaporeans.
Methods
A retrospective cohort study including all adult Singaporeans aged≥18 years was conducted from 1st July 2021-31st October 2022, when a dengue outbreak driven by the DENV3 serotype preceded subsequent waves of SARS-CoV-2 Delta/Omicron transmission in Singapore. SARS-CoV-2 and dengue infection status were classified using national registries. Cox-regression models adjusted for demographics, COVID-19 vaccination status, comorbidity, and socioeconomic-status (SES) were utilized to assess risks and severity (hospitalization, severe illness) of SARS-CoV-2 infection occurring after prior recorded dengue infection.
Results
A total of 3,366,399 individuals were included, contributing 1,399,696,530 person-days of observation. 13,434 dengue infections and 1,253,520 subsequent SARS-CoV-2 infections were recorded; with an average of 94.7 days (S.D=83.8) between dengue infection and SARS-CoV-2 infection. Preceding dengue infection was associated with a modest increase in risk of subsequent SARS-CoV-2 infection (adjusted-hazards-ratio, aHR=1.13, 95%CI=1.08-1.17), and significantly elevated risk of subsequent COVID-19 hospitalization (aHR=3.25, 95%CI=2.78-3.82) and severe COVID-19 (aHR=3.39, 95%CI=2.29-5.03).
Conclusions
Increased risk of SARS-CoV-2 infection and adverse COVID-19 outcomes were observed following preceding dengue infection in a national population-based cohort of adult Singaporeans. This observation is of significance in tropical countries with overlapping dengue and COVID-19 outbreaks.
https://watermark.silverchair.com/o...dSjRN6_N38sjZS9zR4aF3jzejRWPAqwL-mqedP8Gvn1bc
https://doi.org/10.1093/ofid/ofae397
Nicole Tang, Jue Tao Lim, PhD, Borame Dickens, PhD, Calvin Chiew, MPH, Lee Ching Ng, PhD, Po Ying Chia, PhD, Yee Sin Leo, MPH, David Chien Lye, MBBS, Kelvin Bryan Tan, PhD, Liang En Wee, MPH
Abstract
Background and Aims
Elucidating whether prior dengue potentially confers cross-protection against COVID-19 is of public health importance in tropical countries at-risk of overlapping dengue and COVID-19 epidemics. However, studies to-date have yielded conflicting results. We aimed to assess effects of recent prior dengue infection on risk and severity of subsequent SARS-CoV-2 infection amongst adult Singaporeans.
Methods
A retrospective cohort study including all adult Singaporeans aged≥18 years was conducted from 1st July 2021-31st October 2022, when a dengue outbreak driven by the DENV3 serotype preceded subsequent waves of SARS-CoV-2 Delta/Omicron transmission in Singapore. SARS-CoV-2 and dengue infection status were classified using national registries. Cox-regression models adjusted for demographics, COVID-19 vaccination status, comorbidity, and socioeconomic-status (SES) were utilized to assess risks and severity (hospitalization, severe illness) of SARS-CoV-2 infection occurring after prior recorded dengue infection.
Results
A total of 3,366,399 individuals were included, contributing 1,399,696,530 person-days of observation. 13,434 dengue infections and 1,253,520 subsequent SARS-CoV-2 infections were recorded; with an average of 94.7 days (S.D=83.8) between dengue infection and SARS-CoV-2 infection. Preceding dengue infection was associated with a modest increase in risk of subsequent SARS-CoV-2 infection (adjusted-hazards-ratio, aHR=1.13, 95%CI=1.08-1.17), and significantly elevated risk of subsequent COVID-19 hospitalization (aHR=3.25, 95%CI=2.78-3.82) and severe COVID-19 (aHR=3.39, 95%CI=2.29-5.03).
Conclusions
Increased risk of SARS-CoV-2 infection and adverse COVID-19 outcomes were observed following preceding dengue infection in a national population-based cohort of adult Singaporeans. This observation is of significance in tropical countries with overlapping dengue and COVID-19 outbreaks.
https://watermark.silverchair.com/o...dSjRN6_N38sjZS9zR4aF3jzejRWPAqwL-mqedP8Gvn1bc