tetano
Editor, Senior Moderator
Acta Odontol Scand. 2019 May 16:1-8. doi: 10.1080/00016357.2019.1609697. [Epub ahead of print]
[h=1]Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: a randomized controlled trial.[/h] Yamamoto Y[SUP]1[/SUP], Saruta J[SUP]2[/SUP], Takahashi T[SUP]3[/SUP], To M[SUP]4[/SUP], Shimizu T[SUP]5[/SUP], Hayashi T[SUP]2[/SUP], Morozumi T[SUP]6[/SUP], Kubota N[SUP]2[/SUP], Kamata Y[SUP]5[/SUP], Makino S[SUP]7[/SUP], Kano H[SUP]7[/SUP], Hemmi J[SUP]7[/SUP], Asami Y[SUP]7[/SUP], Nagai T[SUP]8[/SUP], Misawa K[SUP]9[/SUP], Kato S[SUP]10[/SUP], Tsukinoki K[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] The purpose of this study was to clarify the influence of consuming yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 (1073R-1-yogurt) on influenza virus-bound salivary immunoglobulin A (IgA) levels, in the elderly residents of nursing homes.
[h=4]METHODS:[/h] A double-blind, parallel-group, randomized controlled trial was conducted with 96 elderly volunteers residing in 2 nursing homes. During the trial, participants consumed 100 g of 1073R-1-yogurt every morning for 12 weeks, whereas the control participants consumed yogurt fermented with a different Lactobacillus strain (control yogurt). Saliva was collected before the trial and after 4, 8 and 12 weeks of yogurt ingestion.
[h=4]RESULTS:[/h] Our data indicated that consumption of 1073R-1-yogurt affected influenza A virus subtype H3N2-bound IgA levels in saliva (p = .001). In addition, saliva flow rate and total IgA levels increased in response to the yogurt intake period in both the 1073R-1 and control yogurt groups (p = .04).
[h=4]CONCLUSIONS:[/h] Our study suggests that continuous daily ingestion of 1073R-1-yogurt may help prevent infection with influenza A virus subtype H3N2 in elderly subjects with weakened immunity, by increasing the production of influenza A virus subtype of H3N2-bound salivary IgA.
[h=4]KEYWORDS:[/h] IgA; Saliva; elderly population; influenza; yogurt
PMID: 31094267 DOI: 10.1080/00016357.2019.1609697
[h=1]Effect of ingesting yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 on influenza virus-bound salivary IgA in elderly residents of nursing homes: a randomized controlled trial.[/h] Yamamoto Y[SUP]1[/SUP], Saruta J[SUP]2[/SUP], Takahashi T[SUP]3[/SUP], To M[SUP]4[/SUP], Shimizu T[SUP]5[/SUP], Hayashi T[SUP]2[/SUP], Morozumi T[SUP]6[/SUP], Kubota N[SUP]2[/SUP], Kamata Y[SUP]5[/SUP], Makino S[SUP]7[/SUP], Kano H[SUP]7[/SUP], Hemmi J[SUP]7[/SUP], Asami Y[SUP]7[/SUP], Nagai T[SUP]8[/SUP], Misawa K[SUP]9[/SUP], Kato S[SUP]10[/SUP], Tsukinoki K[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]OBJECTIVE:[/h] The purpose of this study was to clarify the influence of consuming yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 (1073R-1-yogurt) on influenza virus-bound salivary immunoglobulin A (IgA) levels, in the elderly residents of nursing homes.
[h=4]METHODS:[/h] A double-blind, parallel-group, randomized controlled trial was conducted with 96 elderly volunteers residing in 2 nursing homes. During the trial, participants consumed 100 g of 1073R-1-yogurt every morning for 12 weeks, whereas the control participants consumed yogurt fermented with a different Lactobacillus strain (control yogurt). Saliva was collected before the trial and after 4, 8 and 12 weeks of yogurt ingestion.
[h=4]RESULTS:[/h] Our data indicated that consumption of 1073R-1-yogurt affected influenza A virus subtype H3N2-bound IgA levels in saliva (p = .001). In addition, saliva flow rate and total IgA levels increased in response to the yogurt intake period in both the 1073R-1 and control yogurt groups (p = .04).
[h=4]CONCLUSIONS:[/h] Our study suggests that continuous daily ingestion of 1073R-1-yogurt may help prevent infection with influenza A virus subtype H3N2 in elderly subjects with weakened immunity, by increasing the production of influenza A virus subtype of H3N2-bound salivary IgA.
[h=4]KEYWORDS:[/h] IgA; Saliva; elderly population; influenza; yogurt
PMID: 31094267 DOI: 10.1080/00016357.2019.1609697