Giuseppe
Emeritus
ECDC. Antivirals and Antiviral Resistant Influenza (May 15, 2009, Edited)
Antivirals and Antiviral Resistant Influenza - Monitoring of Influenza antiviral resistance in EU during 2008-09 season
Monitoring of antiviral resistance in EU for the season 2008-09 is currently ongoing.
The coordinators of The Community Network of Reference Laboratories for Human Influenza in Europe (CNRL), routinely collect, analyze and disseminate information on antiviral resistance from Influenza viruses isolated from 25 European (European Union, EEA/EFTA) countries.
The analysis of resistance against Neuraminidase Inhibitors and Adamantanes is done by measuring IC50 values and/or by genotyping of viruses for detection of known drug resistance mutations.
Summary information on antiviral resistance in EU will be published weekly in the EISS bulletin (also featured in the weekly ECDC influenza News)
== Antiviral resistance detected in influenza viruses from European countries during the season 2008/2009, by virus subtype and drug class (updated 15/05/2009)(1) ==
[Virus type and subtype - Resistance to neuraminidase inhibitors: Oseltamivir, Zanamivir - Resistance to M2 inhibitors]
[Isolates tested Resistant - n (%)]
(2) NA = not applicable as M2 inhibitors do not act on influenza B viruses.
(...)
-
<cite cite="http://www.ecdc.europa.eu/en/Health_Topics/influenza/antivirals.aspx">Antivirals and Antiviral Resistant Influenza</cite>
Antivirals and Antiviral Resistant Influenza - Monitoring of Influenza antiviral resistance in EU during 2008-09 season
Monitoring of antiviral resistance in EU for the season 2008-09 is currently ongoing.
The coordinators of The Community Network of Reference Laboratories for Human Influenza in Europe (CNRL), routinely collect, analyze and disseminate information on antiviral resistance from Influenza viruses isolated from 25 European (European Union, EEA/EFTA) countries.
The analysis of resistance against Neuraminidase Inhibitors and Adamantanes is done by measuring IC50 values and/or by genotyping of viruses for detection of known drug resistance mutations.
Summary information on antiviral resistance in EU will be published weekly in the EISS bulletin (also featured in the weekly ECDC influenza News)
== Antiviral resistance detected in influenza viruses from European countries during the season 2008/2009, by virus subtype and drug class (updated 15/05/2009)(1) ==
[Virus type and subtype - Resistance to neuraminidase inhibitors: Oseltamivir, Zanamivir - Resistance to M2 inhibitors]
[Isolates tested Resistant - n (%)]
- A(H3N2) - 653 - 0 - 612 - 0 - 644 - 644 - (100)
- A(H1N1) - 259 - 255 - (98) - 259 - 0 - 124 - 1 - (0)
- A(H1N1)-swl - 3 - 0 - 3 - 0 - 0 - 0
- B - 117 - 0 - 113 - 0 - NA(2) - NA
(2) NA = not applicable as M2 inhibitors do not act on influenza B viruses.
(...)
-
<cite cite="http://www.ecdc.europa.eu/en/Health_Topics/influenza/antivirals.aspx">Antivirals and Antiviral Resistant Influenza</cite>