tetano
Editor, Senior Moderator
Sci Rep. 2012;2:972. doi: 10.1038/srep00972. Epub 2012 Dec 13.
Early Indicators of Disease in Ferrets Infected with a High Dose of Avian Influenza H5N1.
Long JP, Vela EM, Stark GV, Jones KJ, Miller ST, Bigger JE.
Source
Battelle 505 King Avenue Columbus , Ohio 43201.
Abstract
Avian influenza viruses are widespread in birds, contagious in humans, and are categorized as low pathogenicity avian influenza or highly pathogenic avian influenza. Ferrets are susceptible to infection with avian and human influenza A and B viruses and have been widely used as a model to study pathogenicity and vaccine efficacy. In this report, the natural history of the H5N1 influenza virus A/Vietnam/1203/04 influenza infection in ferrets was examined to determine clinical and laboratory parameters that may indicate (1) the onset of disease and (2) survival. In all, twenty of 24 animals infected with 7 ? 10(5) TCID(50) of A/Vietnam/1203/04 succumbed. A statistical analysis identified a combination of parameters including weight loss, nasal wash TCID(50), eosinophils, and liver enzymes such as alanine amino transferase that might possibly serve as indicators of both disease onset and challenge survival.
PMID:
23240077
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23240077
Early Indicators of Disease in Ferrets Infected with a High Dose of Avian Influenza H5N1.
Long JP, Vela EM, Stark GV, Jones KJ, Miller ST, Bigger JE.
Source
Battelle 505 King Avenue Columbus , Ohio 43201.
Abstract
Avian influenza viruses are widespread in birds, contagious in humans, and are categorized as low pathogenicity avian influenza or highly pathogenic avian influenza. Ferrets are susceptible to infection with avian and human influenza A and B viruses and have been widely used as a model to study pathogenicity and vaccine efficacy. In this report, the natural history of the H5N1 influenza virus A/Vietnam/1203/04 influenza infection in ferrets was examined to determine clinical and laboratory parameters that may indicate (1) the onset of disease and (2) survival. In all, twenty of 24 animals infected with 7 ? 10(5) TCID(50) of A/Vietnam/1203/04 succumbed. A statistical analysis identified a combination of parameters including weight loss, nasal wash TCID(50), eosinophils, and liver enzymes such as alanine amino transferase that might possibly serve as indicators of both disease onset and challenge survival.
PMID:
23240077
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/23240077