tetano
Editor, Senior Moderator
J Infect Dis. 2017 Jul 18. doi: 10.1093/infdis/jix328. [Epub ahead of print]
[h=1]Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus.[/h] Yoon SW[SUP]1,[/SUP][SUP]2[/SUP], Wong SS[SUP]1[/SUP], Zhu H[SUP]3,[/SUP][SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Chen R[SUP]3[/SUP], Li L[SUP]3[/SUP], Zhang Y[SUP]3[/SUP], Guan Y[SUP]3,[/SUP][SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Webby RJ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Pregnancy has been associated with severe influenza, an association highlighted during the 2009 pandemic of influenza A(H1N1) virus (A[H1N1]pdm09) infection. To assess the underlying mechanism, we infected pregnant and non-pregnant ferrets with A(H1N1) pdm09 virus. A(H1N1)pdm09-infected pregnant ferrets also had higher levels of inflammatory cytokines in their pulmonary tracts. Systemically, total CD8+ T cell counts and A(H1N1)pdm09-specific B-cell responses in blood were significantly lower in pregnant ferrets. This model predicts that the poorer outcome for pregnant women during the A(H1N1)pdm09 pandemic was due to an elevated level of viral replication and to a cytokine imbalance that led to a less effective immune response.
? The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] Pregnancy; immune response; pandemic influenza A virus
PMID: 28973317 DOI: 10.1093/infdis/jix328
[h=1]Dysregulated T-Helper Type 1 (Th1):Th2 Cytokine Profile and Poor Immune Response in Pregnant Ferrets Infected With 2009 Pandemic Influenza A(H1N1) Virus.[/h] Yoon SW[SUP]1,[/SUP][SUP]2[/SUP], Wong SS[SUP]1[/SUP], Zhu H[SUP]3,[/SUP][SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Chen R[SUP]3[/SUP], Li L[SUP]3[/SUP], Zhang Y[SUP]3[/SUP], Guan Y[SUP]3,[/SUP][SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Webby RJ[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Pregnancy has been associated with severe influenza, an association highlighted during the 2009 pandemic of influenza A(H1N1) virus (A[H1N1]pdm09) infection. To assess the underlying mechanism, we infected pregnant and non-pregnant ferrets with A(H1N1) pdm09 virus. A(H1N1)pdm09-infected pregnant ferrets also had higher levels of inflammatory cytokines in their pulmonary tracts. Systemically, total CD8+ T cell counts and A(H1N1)pdm09-specific B-cell responses in blood were significantly lower in pregnant ferrets. This model predicts that the poorer outcome for pregnant women during the A(H1N1)pdm09 pandemic was due to an elevated level of viral replication and to a cytokine imbalance that led to a less effective immune response.
? The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] Pregnancy; immune response; pandemic influenza A virus
PMID: 28973317 DOI: 10.1093/infdis/jix328