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Dromedary MERS-CoV replicates in human respiratory tissues

Shiloh

Shiloh

Editor, Senior Moderator
Source: http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(14)70184-5/fulltext?rss=yes


The Lancet Respiratory Medicine, Early Online Publication, 29 August 2014
doi:10.1016/S2213-2600(14)70184-5

Dromedary MERS-CoV replicates in human respiratory tissues
Leslie A Reperant , Albert D M E Osterhaus

Since its discovery in the autumn of 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has caused more than 800 laboratory-confirmed cases of human infection, with a case-fatality rate of about a third. 1 Patients admitted to hospital with MERS are characterised by symptoms of severe pneumonia...
 
Re: Dromedary MERS-CoV replicates in human respiratory tissues

Source: http://www.thelancet.com/journals/lanres/article/PIIS2213-2600(14)70158-4/abstract?rss=yes

The Lancet Respiratory Medicine

The Lancet Respiratory Medicine, Early Online Publication, 29 August 2014
doi:10.1016/S2213-2600(14)70158-4

Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study

Renee W Y Chan PhD a b ?, Maged G Hemida PhD d f ?, Ghazi Kayali PhD g ?, Daniel K W Chu PhD a b, Leo L M Poon DPhil a b, Prof Abdelmohsen Alnaeem PhD e, Mohamed A Ali PhD h, Kin P Tao PhD a b, Hoi Y Ng MPhil a b, Michael C W Chan PhD a b, Prof Yi Guan PhD a b, Prof John M Nicholls FRCPA c Corresponding AuthorEmail Address, Prof J S Malik Peiris DPhil a b Corresponding AuthorEmail Address

Summary

Background
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic infection causing severe viral pneumonia, with index cases having resided in or recently travelled to the Arabian peninsula, and is a global concern for public health. Limited human-to-human transmission, leading to some case clusters, has been reported. MERS-CoV has been reported in dromedary camels but phenotypic characterisation of such viruses is limited. We aimed to compare MERS-CoV isolates from dromedaries in Saudi Arabia and Egypt with a prototype human MERS-CoV to assess virus replication competence and cell tropism in ex-vivo cultures of human bronchus and lung...
 
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