tetano
Editor, Senior Moderator
[h=1]Does influenza vaccination modify influenza disease severity? Data on older adults hospitalized with influenza during the 2012−13 season in the United States[/h]
[h=2]Abstract[/h] Background. Some studies suggest that influenza vaccination might be protective against severe influenza outcomes in vaccinated persons who become infected. We used data from a large surveillance network to further investigate the effect of influenza vaccination on influenza disease severity in adults aged ≥50 years hospitalized with laboratory-confirmed influenza.
Methods. We analyzed influenza vaccination and influenza severity using Influenza Hospitalization Surveillance Network (FluSurv-NET) data for the 2012−13 influenza season. Intensive care unit (ICU) admission, death, diagnosis of pneumonia, and hospital and ICU lengths of stay served as measures of disease severity. Data were analyzed by multivariable logistic regression, parametric survival models and propensity score matching (PSM).
Results. Overall, no differences in severity were observed in the multivariable logistic regression model. Using PSM, adults aged 50−64 years (but not other age groups) who were vaccinated against influenza had a shorter ICU length of stay compared to those unvaccinated (HR for discharge=1.84, 95% CI: 1.12−3.01).
Conclusion. Our findings show a modest effect of influenza vaccination on disease severity. Analysis of data from seasons with different predominant strains and higher estimates of vaccine effectiveness are needed.
http://jid.oxfordjournals.org/content/early/2015/03/26/infdis.jiv200.short?rss=1
- Carmen S. Arriola1,2,
- Evan J. Anderson3,4,
- Joan Baumbach5,
- Nancy Bennett6,
- Susan Bohm7,
- Mary Hill8,
- Mary Lou Lindegren9,
- Krista Lung10,
- James Meek11,
- Elizabeth Mermel12,
- Lisa Miller13,
- Maya L. Monroe14,
- Craig Morin15,
- Oluwakemi Oni16,
- Arthur Reingold17,
- William Schaffner9,
- Ann Thomas18,
- Shelley M. Zansky19,
- Lyn Finelli2 and
- Sandra S. Chaves2
- Corresponding Author: Carmen Sofia Arriola, Influenza Division, National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention, 1600 Clifton Rd MS A-32, Atlanta, GA 30333, United States of America; telephone: 404-718-4589; fax: 404-639-3866; email: wus3@cdc.gov.
- Alternate Corresponding Author: Sandra Chaves, Influenza Division, National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention, 1600 Clifton Rd MS A-20, Atlanta, GA 30333, United States of America; telephone: 404-639-2797; fax: 404-639-3866; email: schaves@cdc.gov.
[h=2]Abstract[/h] Background. Some studies suggest that influenza vaccination might be protective against severe influenza outcomes in vaccinated persons who become infected. We used data from a large surveillance network to further investigate the effect of influenza vaccination on influenza disease severity in adults aged ≥50 years hospitalized with laboratory-confirmed influenza.
Methods. We analyzed influenza vaccination and influenza severity using Influenza Hospitalization Surveillance Network (FluSurv-NET) data for the 2012−13 influenza season. Intensive care unit (ICU) admission, death, diagnosis of pneumonia, and hospital and ICU lengths of stay served as measures of disease severity. Data were analyzed by multivariable logistic regression, parametric survival models and propensity score matching (PSM).
Results. Overall, no differences in severity were observed in the multivariable logistic regression model. Using PSM, adults aged 50−64 years (but not other age groups) who were vaccinated against influenza had a shorter ICU length of stay compared to those unvaccinated (HR for discharge=1.84, 95% CI: 1.12−3.01).
Conclusion. Our findings show a modest effect of influenza vaccination on disease severity. Analysis of data from seasons with different predominant strains and higher estimates of vaccine effectiveness are needed.
http://jid.oxfordjournals.org/content/early/2015/03/26/infdis.jiv200.short?rss=1