Discussion: Low-risk bird flu found in Ill. wild ducks-USDA

[AlaskaDenise]

Re: Discussion: Low-risk bird flu found in Ill. wild ducks-USDA

.......Please be aware that the HA segment of the 1918 H1N1 virus did not contain mutliple basic amino acids at the cleavage site, at least all the sequences that we have would indicate that, and none of the later isolates had anything unusual at the cleavage site.....

1918 H1N1 accomplished the same objective (high volume cleavage) another way - a mutation (on the NA I believe) that caused it to bind with the plaminogen (enzyme in all blood), so anywhere the blood flowed the virus could cleave! Same result, different mechanism......very high path.

see http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=33880

In a series of experiments confirming and synthesizing 25 years of experimental data (2?4), Goto and Kawaoka (1) demonstrate specifically how the neuraminidase (NA) protein of influenza A/WSN/33 (H1N1), a curious variant of the first human influenza virus ever isolated, mediates hemagglutinin (HA) cleavage. Goto and Kawaoka (1) provide evidence for a model whereby the NA of WSN/33 directly binds plasminogen, sequestering it for cleavage activation. Subsequently, active plasmin cleaves and activates influenza hemagglutinin. Being able to sequester plasminogen for hemagglutinin cleavage allows the influenza virus to infect cells other than its usual targets.

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[Niko]

Re: Discussion: Low-risk bird flu found in Ill. wild ducks-USDA

see http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=33880
Being able to sequester plasminogen for hemagglutinin cleavage allows the influenza virus to infect cells other than its usual targets.

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Yep. Sounds like our baby...

Thanks AD.

 

[Niko]

Re: Discussion: Low-risk bird flu found in Ill. wild ducks-USDA

I don't recall hearing if any of the sequences from the USA 2006 have been released. Any one know the status?

 

[HenryN]

Re: Discussion: Low-risk bird flu found in Ill. wild ducks-USDA

I don't recall hearing if any of the sequences from the USA 2006 have been released. Any one know the status?

The US (and Canada) have not even released the H5 serotypes. There appear to be many H5 serotypes being detected in addition to H5N1. In Quebec, one French report indocated H5N2 and H5N6 was detected this year. Last year H5N1, H5N2, H5N3, and H5N9 were detected, but even the final break-down of serotypes for 2005 has not been released (and sequences from only one H5N2 from British Columbia in 2005 have been released so far)

 

[Harriet]

Re: Discussion: Low-risk bird flu found in Ill. wild ducks-USDA

Just posted low path found in Lakeport CA.

http://www.flutrackers.com/forum/showthread.php?p=35489#post35489

Inquired and awaiting response as to the type of duck found dead.

 

[Harriet]

Re: Discussion: Low-risk bird flu found in Ill. wild ducks-USDA

GLIDE Number BH-20060930-7788-USA
Event type Biological Hazard Date / time [UTC] 30/09/2006 - 03:59:38 (Military Time, UTC)
Country USA Area Fulton County / Rice Lake Conservation
County / State Illinois City -
Cause of event Unknow Log date 30/09/2006 - 03:59:38 (Military Time, UTC)
Damage level Moderate Time left -
Latitude: N 40? 27.700 Longitude: W 89? 55.400
Number of deaths: Not or Not data Number of injured persons: Not or Not data
Evacuated: - Infected -

DESCRIPTION
Wild Green-winged Teal ducks in central Illinois have tested positive for a low-pathogenic strain of avian influenza, the government said on Friday. "Initial tests confirm that these wild duck samples do not contain the highly pathogenic H5N1 strain that has spread through birds in Asia, Europe and Africa," the Agriculture and Interior departments said in a statement. Five of 11 samples taken from the ducks tested positive for the H5 virus subtype and one contained the H5 and N1 subtypes, they said. The samples were sent to a federal laboratory in Ames, Iowa, for further testing of virus strains. The samples were collected on Sunday at the Rice Lake Conservation area in Fulton County, central Illinois. The ducks showed no signs of illness, which also indicates a low-risk strain of avian influenza.

http://visz.rsoe.hu/alertmap/woalert_read.php?id=7788&cat=dis&lang=eng

National Association of Radio-Distress Signalling and Infocommunications,
Havaria Emergency and Disaster Information Services
Budapest Hungary